雌激素暴露对人工冷解胚胎移植周期怀孕结果的影响
Chaofeng Wei1, Haicui Wu2, Yi Yu2
1First College of Clinical Medicine, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China.
概括
在冷解胚胎移植 (FET) 周期中优化雌激素治疗是关键. 本综述强调,虽然较短的雌激素暴露可能会增加流产风险,但长期使用没有普遍的益处,过度使用可以降低活产率.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 辅助生殖技术 辅助生殖技术
背景情况:
- 在全球范围内,玻璃化增加了冷解胚胎移植 (FET) 周期.
- 激素替代疗法 (HRT) 在FET中对子宫内膜制备至关重要.
- 雌激素对子宫内膜接受性至关重要,但最佳的HRT协议缺乏共识.
研究的目的:
- 对FET的HRT中雌激素治疗的当前知识进行审查.
- 讨论最优的持续时间,剂量,途径和目标血清雌激素水平.
- 为FET周期的临床实践提供指导.
主要方法:
- 在FET周期的HRT中使用雌激素的综合文献综述.
- 对针对雌激素持续时间,剂量,途径和血清水平的研究进行分析.
- 综合发现,以确定最佳和潜在的有害雌激素暴露参数.
主要成果:
- 较短的雌激素暴露可能会增加早期流产的风险.
- 长时间暴露于雌激素对大多数患者来说没有明显的优势.
- 在孕激素之前过度的雌激素水平可能会降低活产率 (LBR).
结论:
- 雌激素的持续时间和水平显著影响FET的结果.
- 需要进一步的大规模前性研究来确定最佳的雌激素协议.
- 个性化雌激素治疗可能是有益的,特别是对于薄的子宫内膜.
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