怀孕早期的母体甲状腺功能和孩子的学校表现和神经发育障碍
Line Tang Møllehave1, Mia Klinten Grand2, Margit Kriegbaum2
1Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, 2000 Frederiksberg, Denmark.
The Journal of clinical endocrinology and metabolism
|May 23, 2024
概括
怀孕早期母亲的甲状腺激素水平并没有影响孩子的学业成绩或注意力缺陷多动症 (ADHD) 和自闭症谱系障碍 (ASD) 的风险. 这项研究没有发现任何显著的关联. 关键词:母亲的甲状腺激素,怀孕,儿童发育,多动症,自闭症.
科学领域:
- 神经科学是一个神经科学.
- 内分泌学 在内分泌学.
- 发展生物学 发展生物学
背景情况:
- 甲状腺激素对于胎儿的神经发育至关重要.
- 胎儿在怀孕的第一季度完全依赖母亲的甲状腺激素.
研究的目的:
- 为了检查第一季度母亲甲状腺激素水平和儿童的学业成绩之间的关系.
- 研究母亲甲状腺激素水平与后代注意力缺陷多动症障碍 (ADHD) 和自闭症谱系障碍 (ASD) 风险之间的关联.
主要方法:
- 利用了来自哥本哈根初级保健实验室怀孕数据库的数据,将母亲的甲状腺刺激激素 (TSH) 和自由甲状腺素测量与儿童的结果联系起来.
- 采用线性混合模型和考克斯回归来评估关联,根据先前存在的母体甲状腺疾病进行分层分析.
- 包括ADHD和ASD风险分析的17,909个母婴二位数,以及学校绩效分析的6,126个.
主要成果:
- 在第一季度母亲甲状腺激素水平和儿童标准化学校测试成绩之间没有发现任何关联.
- 怀孕早期母亲的甲状腺激素水平与儿童患ADHD或ASD的风险没有关联.
- 根据先前存在的母体甲状腺疾病进行分层分析并没有改变观察到的结果.
结论:
- 这项研究发现,没有证据表明,第一季度母亲甲状腺激素水平与孩子的学业成绩有关.
- 在怀孕早期母亲甲状腺激素水平与ADHD或ASD风险之间没有发现任何关联.
- 这些发现表明,怀孕早期母亲的甲状腺功能可能不是这些特定神经发育结果的重要因素.
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