肉瘤免疫疗法:当前数据和有前途的策略
Georgina E Wood1, Christian Meyer2, Florent Petitprez3
1University College Hospital of London, London, United Kingdom.
概括
曾经被认为是免疫沉默的瘤,显示出免疫治疗的潜力. 一些骨和软组织瘤是骨和软组织瘤.
科学领域:
- 瘤学和免疫学
背景情况:
- 瘤传统上表现出低瘤突变负担 (TMB) 和免疫抑制瘤微环境 (TME).
- 然而,一小部分的瘤在免疫学上是"热"的,具有高的TMB,PD-L1表达,CD8+T细胞或三级淋巴体结构 (TLS).
- 这些"热"瘤对免疫疗法表现出敏感性.
研究的目的:
- 审查有关骨肉瘤 (BS) 和软组织肉瘤 (STS) 免疫治疗的现有证据.
- 探索各种免疫治疗方式和反应的生物标志物.
主要方法:
- 对骨和软组织肉瘤的免疫治疗现有研究的审查.
- 免疫检查点抑制剂 (ICI) 和采用细胞疗法的分析.
- 对嵌合式抗原受体 (CAR) T细胞疗法,瘤透性淋巴细胞 (TILs) 和癌症疫苗的检查.
主要成果:
- 有证据表明,某些瘤对免疫疗法有反应.
- 免疫检查点抑制剂 (ICI) 和采用细胞疗法是有前途的.
- 生物标志物对于预测对这些治疗的反应至关重要.
结论:
- 免疫疗法代表了针对特定类型的瘤亚型的治疗日益增长的领域.
- 对生物标志物和新型治疗策略的进一步研究是有必要的.
- 准免疫微环境有可能改善肉瘤的结果.
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