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Updated: Jun 25, 2025

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发现,优化和生物活性评估基尼衍生物作为潜在的KRAS G12D抑制剂

Ran Sun1, Yangfan Hu1, Xiangwen Liu1

  • 1School of Pharmaceutical Sciences, Shanghai Jiao Tong University, No. 800 Dongchuan Rd. Minhang District, Shanghai 200240, PR China.

Bioorganic chemistry
|May 23, 2024
PubMed
概括

新的基尼衍生物在对抗KRAS G12D突变癌症方面表现有前途. 在临床前模型中,一种化合物SK12有效地减少了瘤生长,并诱导了癌细胞死亡.

关键词:
这是一种抗癌药物.杰尼平衍生品的衍生品KRAS G12D 抑制剂的使用

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