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全大脑内在的功能连接预测了早期精神病的症状和功能

Jason Smucny¹, Korey P Wylie², Tyler A Lesh¹

¹Department of Psychiatry and Behavioral Sciences, University of California, Davis, USA.

Journal of psychiatric research

|May 23, 2024

概括

早期精神病 (EP) 中大脑连接的改变与症状严重程度和功能障碍有关. 这项研究强调了功能连接性作为精神病症状的潜在生物标志物.

科学领域:

神经科学是一个神经科学.
精神病学是一个精神病学.
医疗成像医学成像

背景情况:

精神病的理论提出异常的内在功能连接是潜在的积极和混乱的症状.
这种功能障碍也可能导致精神病患者的整体功能受损.

研究的目的:

评估精神病症状与早期精神病 (EP) 中的全球功能连接异常之间的关联.
研究功能连接性作为精神病症状的潜在生物标志物.

主要方法:

休息状态功能磁共振成像 (fMRI) 用于108名EP患者和86名健康对照者 (HCs).
通过将个人连接与平均HC连接矩阵相关联来计算全球内在连接相似度指数.
分析使用了谢弗的地图集,其中包括100,200,300和400个区域分片.

主要成果:

连接性相似性与症状严重程度有负相关性 (简要精神病学评分尺度,积极症状评估尺度,混乱症状).
更高的连接相似性与全球功能评估分数正相关.
结果在不同的土地分割方案中保持一致,不受性别或诊断的影响.

结论:

全脑功能连接模式的变化与早期精神病的精神病症状有关.
功能性连接是EP中精神病症状和功能障碍的一个有前途的生物标志物.

关键词:

生物标志物生物标志物双极性障碍是一种双极性障碍.休息状态休息状态精神分裂症是一种精神分裂症.功能磁力共振成像 (fMRI) 是一种

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