菌:它们的管理有多异质?
Coumba Diop1, Julie Descy1, Rosalie Sacheli2
1Clinical laboratory, Andre Renard Hospital, Liege, Belgium.
Diagnostic microbiology and infectious disease
|May 23, 2024
概括
细菌菌菌的真菌病正在增加,特别是在高风险患者中. 发现了富洛可纳耐药性,但伏利可纳和赤甘丁在治疗这种酵母菌感染方面表现有前途.
科学领域:
- 医学真菌学 医学真菌学
- 传染性疾病 传染性疾病
- 临床微生物学 临床微生物学
背景情况:
- 常见的益生菌Saccharomyces cerevisiae越来越多地与真菌病有关.
- 增加S. cerevisiae真菌病的发病率,特别是在免疫受损的个体中.
- 在患有S. cerevisiae真菌病的患者中,易感因素是常见的.
研究的目的:
- 分析S. cerevisiae真菌病的临床相关性和治疗管理.
- 为了评估S. cerevisiae分离物的抗真菌易感性模式.
- 确定临床管理中的差异以及需要治疗指南的需要.
主要方法:
- 对21例S. cerevisiae真菌病例 (2000-2022) 的回顾性分析.
- 对患者的风险因素,临床表现和治疗结果的审查.
- 抗真菌敏感性测试,包括最小抑制度 (MIC).
主要成果:
- 所有患者都有一个或多个诱发真菌病的风险因素.
- 隔离物显示了高的可纳MIC,但低的AMPHOTERICIN B,沃里可纳和埃奇诺坎丁的MIC.
- 观察到多样化的临床管理,包括抗真菌疗法或设备移除.
结论:
- 沃里康纳和赤甘是弗卢康纳和B类安福特素的可行的替代品.
- S. cerevisiae真菌病需要谨慎监测,类似于候选病,包括后续培养和对转移焦点的评估.
- 管理S. cerevisiae感染的显著变化强调了需要标准化的临床指导方针.
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