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在中国北京,人类乳腺炎中社区相关的金黄色葡萄球菌分离物的流行率和特征

Jihong Gu¹, Mengyuan Xiong¹, Jing Zhang²

¹Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China.

International journal of medical microbiology : IJMM

|May 23, 2024

概括

这项研究在乳腺炎病例中确定了占主导地位的金黄色葡萄球菌 (S. aureus) 克隆,CC22和CC59. 对ST22EMRSA-15的警至关重要,因为它有可能广泛感染.

科学领域:

微生物学微生物学
流行病学流行病学
遗传学是一个遗传学.

背景情况:

黄金葡萄球菌 (S. aureus) 是一种全球性病原体,引起乳腺炎,对公共卫生有重大影响.
了解S. aureus菌株的分子特性对于有效的感染控制至关重要.

研究的目的:

为了研究导致乳腺炎的S. aureus的分子类型,抗生素耐药性和毒性基因配置文件.
确定主导的黄金菌克隆并评估它们对公众健康的威胁.

主要方法:

分析使用多位序列类型 (MLST) 和spa类型的乳腺炎患者的200个S. aureus分离物.
用于病毒性基因查的聚合酶链反应 (PCR) 和VITEK® 2 抗生素敏感性测试的紧系统.

主要成果:

在77.0%的分离物中发现了占主导地位的克隆ST22;MRSA (耐甲基黄金葡萄球菌) 占19.0%.
MRSA分离物主要是CC22和CC59. 对于β-乳酸和宏化物,观察到高耐药率 (>50%).
在ST22-MRSA菌株中,pvl的携带率很高 (84.2%). 与MSSA (甲素敏感黄金葡萄球菌) 相比,MRSA分离物具有较高的脂质和pvl检测率.

结论:

分子流行病学对于追踪黄金色杆菌传播至关重要.
在该地区,对MRSA克隆CC22和CC59需要提高警.
需要注意的是,ST22 EMRSA-15的潜在流行传播需要注意.

关键词:

社区相关的甲素耐药金黄色细菌 (CA-MRSA)乳腺炎是一种乳腺炎.分子类型的定型.黄金葡萄球菌黄金葡萄球菌整个基因组的测序.

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