相关实验视频

Updated: Jun 25, 2025

Co-transplantation of Human Ovarian Tissue with Engineered Endothelial Cells: A Cell-based Strategy Combining Accelerated Perfusion with Direct Paracrine Delivery

Co-transplantation of Human Ovarian Tissue with Engineered Endothelial Cells: A Cell-based Strategy Combining Accelerated Perfusion with Direct Paracrine Delivery

Published on: May 16, 2018

通过使用人类多能干细胞衍生的介质细胞前代细胞来保护卵巢功能

Dong Ryul Lee^1,2,3, Jeoung Eun Lee³

¹Department of Biomedical Science, College of Biological Science, CHA University, Seongnam, Republic of Korea.

Clinical and experimental reproductive medicine

|May 23, 2024

概括

人类多能干细胞衍生的介质细胞前代细胞 (hPSC-MPCs) 在老化和化疗损伤的卵巢中保持卵巢功能具有前景. 这种方法可以为面对生殖挑战的妇女提供新的生育保护选择.

科学领域:

生殖生物学生殖生物学
干细胞疗法是一种干细胞疗法.
老年学是指老年学的学科.

背景情况:

卵巢储备自然会随着年龄的增长而减少,影响生育能力和健康.
癌症治疗可以导致卵巢损伤,减少年轻女性的生育能力.
目前用于保护卵巢的治疗方法有限.

研究的目的:

审查人类多能干细胞衍生中原细胞 (hPSC-MPCs) 对于卵巢保护的潜力.
要突出hPSC-MPCs对卵巢功能在衰老和化疗诱导的损伤模型的影响.

主要方法:

在雌性小鼠模型中研究hPSC-MPCs的研究的综述.
对hPSC-MPCs对卵巢衰老和化疗引起的损伤的影响的分析.
评估hPSC-MPCs的繁殖能力和遗传稳定性.

主要成果:

hPSC-MPCs在老化小鼠模型中显示出对卵巢衰老的保护作用.
在接受化疗的小鼠模型中,hPSC-MPCs有助于保持卵巢功能.
hPSC-MPCs具有高的繁殖能力和治疗用途的遗传稳定性.

结论:

hPSC-MPCs 是一个有前途的细胞来源,可以保护生育能力.
这种细胞治疗方法可能会延迟生殖衰老,并防止治疗引起的卵巢损伤.
hPSC-MPC为患有影响生育能力的各种疾病的妇女提供了潜力.

关键词:

保存生育能力保护生育能力人类胚胎干细胞衍生中酶体前代细胞.人类多能干细胞衍生的介质细胞前代细胞.卵巢衰老的发生生殖衰老是一种生殖衰老.

更多相关视频

The Chick Chorioallantoic Membrane CAM Model as a Tool to Study Ovarian Tissue Transplantation

The Chick Chorioallantoic Membrane CAM Model as a Tool to Study Ovarian Tissue Transplantation

Published on: June 23, 2023

Author Spotlight: Advancing Human Ovarian Repair and Cancer Studies with Surface Epithelium Organoids

Author Spotlight: Advancing Human Ovarian Repair and Cancer Studies with Surface Epithelium Organoids

Published on: August 16, 2024

相关概念视频

Induced Pluripotent Stem Cells

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic...

Embryonic Stem Cells

Embryonic Stem Cells

Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...