阴性,凝形成的输送系统用于阴道药物给药
Rachel L Shapiro1, Kimberly M Bockley2, Henry T Hsueh3
1Department of Chemical and Biomolecular Engineering, Johns Hopkins University, 3400 N. Charles Street, Baltimore, MD 21218, USA; The Center for Nanomedicine, The Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
概括
这项研究引入了一种新的低压,凝形成的阴道药物输送系统. 这种基于Pluronic的创新系统为治疗女性生殖道疾病提供了更好的疗效和更少的副作用.
科学领域:
- 生物材料科学 生物材料科学
- 药品制造 药品制造 药品制造
- 生殖医学 生殖医学
背景情况:
- 在女性生殖道 (FRT) 疾病中,最好通过阴道输送药物,以最大限度地减少全身副作用.
- 现有的阴道产品,如戒指和奶油,具有排泄和排泄等限制.
研究的目的:
- 开发和描述一种新的低压,凝形成的基于Pluronic的输送系统,用于阴道输送.
- 与商业产品相比,评估这个新系统的有效性和好处.
主要方法:
- 普鲁罗尼克F127配方的风湿性质的表征.
- 在小鼠阴道中测定Pluronic F127度的低压凝.
- 使用孕激素纳米悬浮剂 (ProGel) 预防早产 (PTB) 的体内疗效研究以及体内排泄和细菌相容性的评估.
主要成果:
- 低压,凝形成系统在小鼠阴道中形成了一层均的凝层.
- 在预防化学诱导的PTB方面,ProGel表现出相当于Crinone®的疗效.
- ProGel显著降低了排泄,毒性,并改善了体外阴道细菌的兼容性.
结论:
- 低压,凝形成的输送系统为阴道治疗提供了一个有前途的替代方案.
- 这种新的系统提高了药物输送到FRT的速度,改善了患者的合规性和安全性.
相关概念视频
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The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
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01:22Drug Delivery: Miscellaneous Routes
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01:18Drug Delivery: Enteral Route
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01:29Drug Delivery: Parenteral Route
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01:18Routes of Drug Administration: Enteral
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