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牛白血病病毒分子检测和相关因素在哥伦比亚安蒂奥克亚的奶牛牧场工人
Willington Mendoza1, Juan Pablo Isaza1, Lucelly López2
1Grupo Biología de Sistemas, Escuela de Ciencias de la Salud, Facultad de Medicina, Universidad Pontificia Bolivariana. Medellín, Colombia.
Acta tropica
|May 23, 2024
概括
牛白血病病毒 (BLV) 在哥伦比亚安提奥克亚的乳制品工人中被检测到13%. 鉴定了BLV基因型1,这表明潜在的动物传播,特别是在那些手术材料事故.
科学领域:
- 兽医医学 兽医医学 兽医医学
- 病毒学 病毒学
- 流行病学 流行病学
背景情况:
- 牛白血病病毒 (BLV) 是一种牛病原体,与淋巴瘤有关.
- 目前正在调查BLV的动物感染潜力,但在乳制品工人等人类群体中存在未知的流行率.
- 之前的研究表明,BLV基因型1在安提阿基亚的牛中循环.
研究的目的:
- 为了确定哥伦比亚安蒂奥克亚的奶牛农场工人中BLV检测频率.
- 为了确定这种人群中存在的BLV基因型.
- 探索与乳制品工人中BLV检测相关的因素.
主要方法:
- 一项涉及安提奥克亚51个牛群的164名奶牛场工人的横截面研究.
- 使用嵌套PCR和qPCR进行BLV env和tax基因的分子检测.
- 用于BLV基因型定制的测序和遗传学分析,以及二变量和多变量统计建模.
主要成果:
- 在13% (22/164) 的参与者中检测到BLV env基因;没有检测到税基因.
- BLV基因型 1 通过分子分化被确定.
- 使用外科材料的事故与BLV阳性相关 (PRa = 2.70).
结论:
- 这些发现表明,BLV基因型1的动物传播可能是从牛群传播给安提阿基亚的奶制品工人.
- BLV阳性和手术材料事故之间的关联突出了潜在的职业风险.
- 需要进一步的研究来确定BLV作为畜牧业养殖者病因病因的作用.
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