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在中国2型糖尿病患者中,A/G比和动脉硬之间的关联:一个横截面研究

Jianmin Wu¹, Ai Chen², Jie Zhang³

¹Department of Geriatrics, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China; Fujian Hypertension Research Institute, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China; Clinical Research Center for Geriatric Hypertension Disease of Fujian Province, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China.

Experimental gerontology

|May 23, 2024

概括

机器人与肌肉脂肪比率 (A/G比率) 与2型糖尿病的动脉硬有关. 一种新的纳米图,包括A/G比,有助于预测动脉硬的风险,特别是在正常的BMI个体.

科学领域:

内分泌学在内分泌学.
心血管医学心血管医学
代谢健康代谢健康

背景情况:

动脉硬是心血管风险标志物.
安卓与肌肉脂肪比 (A/G比) 是一个独立于BMI的肥胖指标.
在2型糖尿病 (T2DM) 中,A/G比与动脉硬之间的关联需要进一步研究.

研究的目的:

开发一种用于预测T2DM患者动脉硬性的名图.
探索A/G比率与传统肥胖指标对动脉硬性的相互作用.
评估A/G比在确定心血管疾病风险方面的临床实用性.

主要方法:

分析了1313名T2DM患者的队列.
动脉硬度是通过手臂脚脉冲波速度 (baPWV) 进行评估的.
通过LASSO和物流回归模型构建了一个预测名录,并通过ROC和DCA验证.

主要成果:

六个预测因素 (年龄,性别,A/G比,SBP,LDL-C,HbA1c) 已被确定为名图.
诺米图表显示出高的预测准确性 (AUC培训:0.918,外部:0.833).
A/G比率和BMI协同增加了动脉硬的风险;升高的A/G比率是显著的风险因素,特别是在正常的BMI个体中.

结论:

开发的名图有效地预测T2DM的动脉硬性.
A/G比是动脉硬的重要预测因素,特别是在正常BMI的个体中.
测量A/G比率可以帮助在T2DM中早期识别心血管疾病.

关键词:

体脂肪与体脂肪的比率是什么动脉的硬性动脉的硬性相互作用效应的相互作用效应.这个名字叫做Nomogram.2型糖尿病是什么? 2型糖尿病是什么

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