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Updated: Apr 19, 2026

A Proinflammatory, Degenerative Organ Culture Model to Simulate Early-Stage Intervertebral Disc Disease.
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通过微阵列数据分析识别与脊椎间盘退化相关的自相关基因

Miao Ma1, Guifu Ma2, Chao Zhang2

  • 1Department of Orthopedics, The Second Clinical Medical College, Lanzhou University, Lanzhou, Gansu, China; Department of Orthopaedics, Lanzhou University Second Hospital, Lanzhou, China.

World neurosurgery
|May 23, 2024
PubMed
概括

研究人员确定了九个关键的自相关基因作为椎间盘退化潜在的生物标志物. 这些发现为了解和潜在地治疗这种疾病提供了新的途径.

关键词:
与自相关的基因与自有关.生物信息学分析竞争的内源性RNA具有竞争性.椎间盘退化 椎间盘退化细胞的核是脉细胞.

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Herniated Intervertebral Disc l: Introduction01:29

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Intervertebral disc herniation refers to the displacement of the nucleus pulposus (the gel-like inner core of the disc) through a tear or weakened area in the annulus fibrosus (the outer fibrous ring). The displaced disc material extends beyond the normal boundaries of the disc space and may compress or irritate nearby spinal nerve roots or, less commonly, the spinal cord.Etiology and Risk FactorsHerniation commonly results from degeneration, in which aging reduces disc hydration and...
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Degenerative disc disease is a chronic condition in which intervertebral discs gradually lose structure and function. It is not infectious or autoimmune; rather, it results from age-related biochemical and mechanical changes, influenced by genetic, metabolic, and environmental factors.Structure and Function of DiscsThe spine contains 23 intervertebral discs that absorb load, distribute forces, maintain spacing, and allow flexibility. Each disc consists of a nucleus pulposus, a gel-like core...
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The symptoms of degenerative disc disease arise from a combination of mechanical compression, vascular compromise, and biochemical inflammation, which together disrupt nerve function and produce pain.Mechanical CompressionDisc degeneration reduces height and elasticity, predisposing to herniation of the nucleus pulposus, a major cause of radicular pain. Herniations may be protrusion (bulging with intact annulus), extrusion (nucleus extends beyond disc but remains connected), or sequestration...
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