职业暴露和结直肠癌:一个系统的审查和元分析
Michele Sassano1, Monireh Sadat Seyyedsalehi2, Paolo Boffetta3
1Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy.
Environmental research
|May 23, 2024
概括
根据对28项研究的元分析,职业暴露可能会增加结直肠癌 (CRC) 的风险. 需要进一步的研究来证实这种关联,并探索剂量-反应关系.
科学领域:
- 职业健康 职业健康 职业健康
- 流行病学 流行病学
- 毒理学 毒理学 毒理学
背景情况:
- 是一种已知的人类致癌物,与肺癌和膀癌等固体癌症有关.
- 关于与结直肠癌 (CRC) 的关联的证据有限.
- 职业接触是一种严重的公共卫生问题.
研究的目的:
- 系统地审查和分析有关职业暴露与结直肠癌 (CRC) 之间的关联的现有文献.
- 量化与职业暴露相关的CRC发病率和死亡率的风险.
主要方法:
- 在PubMed,Embase和Scopus进行了全面的文献搜索,寻找队列和嵌套病例控制研究.
- 包含的研究的质量评估使用修改后的纽卡斯尔-太华尺度进行.
- 聚合的相对风险 (RRs) 和95%的置信区间 (CI) 使用保勒-曼德尔方法计算.
主要成果:
- 二十八项研究被纳入了元分析,主要来自欧洲和北美.
- 与未暴露的工人相比,CRC发病率和死亡率的聚合RR分别为1.10 (95%CI:1.06,1.15) 和1.04 (95%CI:0.97,1.11).
- 结肠和直肠癌的结果显示了类似的趋势,尽管并非所有结果都达到统计学意义.
结论:
- 这些发现表明,职业暴露与结直肠癌风险增加之间存在潜在的关联.
- 观察到剂量-反应关系的有限证据.
- 需要通过详细的个人暴露评估进行进一步的研究来验证这些发现.
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