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运动和多克索鲁比辛对急性隔膜神经肌肉传输衰竭的影响
Branden L Nguyen1, Dryden R Baumfalk1, Stephanie S Lapierre-Nguyen1
1Department Applied Physiology and Kinesiology, University of Florida, 1864 Stadium Rd., Gainesville, FL 32611, United States of America.
Experimental neurology
|May 23, 2024
概括
多克索鲁比 (DOX) 化疗会通过损害神经肌肉结节引起隔膜软弱. 运动预先调节可以保护隔膜功能和神经肌肉完整性,减少DOX治疗的老鼠的呼吸功能障碍.
科学领域:
- 心血管药理学心血管药理学
- 呼吸系统生理学 呼吸系统生理学
- 神经毒理学 神经毒理学
背景情况:
- 多克索鲁比 (DOX) 是一种重要的化疗剂,但其使用受到非目标毒性,包括呼吸道肌肉衰弱等限制.
- 隔膜功能障碍,以虚弱和呼吸不良为特征,是一个重大问题,但神经毒性的作用仍然不清楚.
研究的目的:
- 调查多克索鲁比诱导的隔膜虚弱是否与神经毒性有关.
- 为了确定运动预调可以保持神经肌肉完整性和改善膜收缩性后多克索鲁比暴露.
主要方法:
- 成年雌性大鼠被分为久坐和运动组,运动包括10天的跑步机跑步.
- 动物接受了多克索鲁比辛 (20 mg/kg) 或盐水,并通过神经和直接肌肉刺激来评估隔膜功能.
- 分析了神经肌肉传播,神经形态以及炎症和神经损伤的生物标志物.
主要成果:
- 在久坐不动的老鼠中,多克索鲁比显著降低了隔膜的特定力,表明肌肉软弱.
- 运动预先调节减弱了多克索鲁比辛诱导的隔膜功能障碍,减少了神经肌肉传输失败.
- 运动还减轻了神经形态的变化,并减少了神经损伤和炎症的循环生物标志物.
结论:
- doxorubicin 诱导的隔膜软弱与影响神经肌肉传导的神经毒性有关.
- 运动预先调节有效地保护隔膜神经肌肉的完整性和功能,提供一个潜在的策略,以减轻Doxorubicin治疗的呼吸系统副作用.
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