营养不良:肌肉消耗,炎症,RDW,以及它们与不良结果的关系
Carlos A Galindo-Martín1, Paola A Chong-Aviña1, Vilma Godinez-Breacher1
1Department of Nutrition, Hospital San Angel Inn Universidad, Mexico City, Mexico.
Cirugia y cirujanos
|May 23, 2024
概括
红细胞分布宽度 (RDW) 没有改善单独或与肌肉衰竭一起的营养不良预测. 营养不良患者的RDW较高,表明炎症和肌肉损失.
科学领域:
- 临床医学 临床医学
- 生物标志物 生物标志物
- 营养科学 营养科学
背景情况:
- 营养不良是住院患者的一个重大问题,与不良结果有关.
- 炎症和肌肉消耗是营养不良的关键组成部分.
- 红细胞分布宽度 (RDW) 是一个很容易测量的参数,反映了红细胞的变化.
研究的目的:
- 评估红细胞分布宽度 (RDW) 作为炎症的替代标志物.
- 评估RDW单独和与肌肉消耗一起预测住院成人的营养不良相关不良结果的能力.
主要方法:
- 一个单一中心的观察性研究包括545名成人住院患者.
- 人口统计数据,营养不良标准和RDW是在入院后24小时内收集的.
- 相关性和回归分析用于将RDW,肌肉消耗和不良结果 (死亡率,重症监护转移) 联系起来.
主要成果:
- 肌肉消耗在所有回归模型中独立预测了不良结果.
- 仅RDW就证明了对不良结果的合理预测性能.
- 结合RDW和肌肉消耗的模型仅与未计划转移到重症监护的关联.
结论:
- RDW没有提高超出肌肉损耗评估的不良结果的预测.
- 营养不良的患者表现出更高的RDW,这可能表明炎症和肌肉损失增加.
- 需要进一步的研究来确定RDW是否可以指导营养支持或作为反应标志物.
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