初级甲状腺功能低下症与代谢功能障碍相关的脂肪性肝病之间的关联:更新的元分析
Alessandro Mantovani1, Alessandro Csermely1, Josh Bilson2
1Endocrinology and Metabolism, University of Verona Faculty of Medicine and Surgery, Verona, Italy.
Gut
|May 23, 2024
概括
初级甲状腺功能低下症显著增加了与代谢功能障碍相关的脂肪性肝病 (MASLD) 的风险及其严重程度. 这一元分析证实了甲状腺功能低下症和肝脏疾病之间的强烈联系.
科学领域:
- 内分泌学 在内分泌学.
- 肝病学 肝病学是一种肝病学.
- 流行病学 流行病学
背景情况:
- 初级甲状腺功能低下与代谢功能障碍相关的脂肪性肝病 (MASLD) 有关.
- 确切的风险大小及其与MASLD严重程度的关系尚未完全理解.
研究的目的:
- 量化一次性甲状腺功能低下症与MASLD风险之间的关联.
- 评估MASLD的风险是否受其组织学严重程度的影响.
主要方法:
- 一项对28项观察性研究 (24项截面,4项纵向) 的系统性元分析,包括约7650万个体.
- 数据来源于PubMed,Scopus和Web of Science,MASLD通过活检,成像或ICD代码进行诊断.
- 使用随机效应建模来分析聚合数据.
主要成果:
- 初级甲状腺功能低下症与43%增加患有流行性MASLD的风险相关 (OR1.43,95%CI1.23-1.66).
- 观察到晚期MASLD (稳肝炎或纤维化) 的风险明显更高 (OR2.84,95% CI2.07-3.90).
- 纵向数据显示,与4.5年的MASLD发展有边际非显著的关联 (HR 1.39,95% CI 0.98-1.97).
结论:
- 初级甲状腺功能低下症与MASLD的患病率增加有显著关联.
- 这项研究提供了证据,将甲状腺功能低下症与MASLD更严重的组织学严重性联系起来.
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