相关实验视频

Updated: Jun 25, 2025

Effect of Artificial Tear Formulations on the Metabolic Activity of Human Corneal Epithelial Cells after Exposure to Desiccation

Effect of Artificial Tear Formulations on the Metabolic Activity of Human Corneal Epithelial Cells after Exposure to Desiccation

Published on: May 2, 2020

[翻译文章]对两种新的无防腐剂甲基普雷迪尼索隆眼滴进行物理化学和微生物稳定性研究

Vicente Merino-Bohórquez¹, Silvia Berisa-Prado², Mercedes Delgado-Valverde³

¹Servicio de Farmacia, Hospital Universitario Virgen Macarena, Sevilla, Spain; Departamento de Farmacología, Facultad de Farmacia, Universidad de Sevilla, Sevilla, Spain.

Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria

|May 23, 2024

概括

没有防腐剂的甲基普雷迪尼索隆糖酸盐 (MTPSS) 眼滴在冷藏下显示出良好的稳定性. 1毫克/毫升的配方稳定21天,10毫克/毫升的配方稳定42天,推开封后使用7天.

科学领域:

眼科医生眼科眼科
制药科学制药科学
药物的稳定性药物的稳定性

背景情况:

没有防护剂的眼滴对于管理诸如Sjögren综合征和干眼综合征等眼部疾病至关重要.
甲基prednisolone糖酸盐 (MTPSS) 是一种皮质类固醇,因其抗炎性而用于眼科应用.

研究的目的:

在90天内评估两种无防腐剂的MTPSS眼滴配方 (1 mg/mL和10 mg/mL) 的物理化学和微生物稳定性.
为了确定这些眼科溶液的最佳储存条件和保质期.

主要方法:

使用注射式MTPSS制备配方,并在冷藏 (5°C),室温 (25°C) 和升高 (40°C) 条件下储存.
使用HPLC-UV对药物含量,pH,度和视觉检查进行了物理化学稳定性的评估.
在冷藏条件下,在开放和关闭的容器中测试了微生物无菌性.

主要成果:

冰箱储存 (5°C) 为两种MTPSS度提供了最佳的稳定性.
在冷藏下,药物的降解率在21天 (1 mg/mL) 和42天 (10 mg/mL) 保持在10%以下.
在5°C时,没有观察到pH或度的显著变化,与其他条件形成沉物或颗粒不同.

结论:

1毫克/毫升的MTPSS眼滴在冷藏下稳定21天,10毫克/毫升的配方稳定42天.
由于没有防腐剂,无论储存条件如何,两种配方都应在打开后7天内使用.
这些发现支持在适当处理时使用无防腐剂的MTPSS眼液治疗特定的眼部疾病.

关键词:

药物的稳定性药物的稳定性干眼综合症干眼综合症药物的稳定性药物的稳定性葡萄糖皮质化物是什么葡萄糖皮质类药物是什么眼科解决方案眼科解决方案斯乔格伦综合征 (Sjogren's Syndrome) 是一种疾病,解决问题的解决方案斯约格伦综合症 (Sjögren-Syndrom) 是一种眼睛干燥症候群 (Syndromes del Ojo Seco Seco) 是一种眼睛干燥症.

更多相关视频

Quantification of the Immunosuppressant Tacrolimus on Dried Blood Spots Using LC-MS/MS

Quantification of the Immunosuppressant Tacrolimus on Dried Blood Spots Using LC-MS/MS

Published on: November 8, 2015

Development of an In Vitro Ocular Platform to Test Contact Lenses

Development of an In Vitro Ocular Platform to Test Contact Lenses

Published on: April 6, 2016

相关概念视频

Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry

Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry

Orally administered drugs primarily enter the systemic circulation via passive diffusion through the intestinal membranes. The drug's absorption is influenced by drug stability in the gastrointestinal GI tract, membrane permeability, the surface area available for absorption, luminal drug concentration, and residence time in the lumen. Drug permeability can be enhanced by adjusting the lipophilicity, polarity, or molecular size of the drug, promoting its passive transport across intestinal...

Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism

Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism

Polymorphism refers to the existence of a drug substance in multiple crystalline forms, known as polymorphs. Recently, this term has been expanded to include solvates (forms containing a solvent), amorphous forms (non-crystalline forms), and desolvated solvates (forms from which the solvent has been removed).
Some polymorphic crystals possess lower aqueous solubility than their amorphous counterparts, leading to incomplete absorption. For instance, the oral suspension of Chloramphenicol, which...