甘油三糖指数与甲状腺疾病之间的关联:一个横截面调查和孟德尔随机化分析
Chenyu Zhang1, Haoyu Wang1, Yongze Li1
1Department of Endocrinology and Metabolism, Institute of Endocrinology, NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Hospital of China Medical University, Shenyang, Liaoning, 110001, PR China.
Endocrine
|May 23, 2024
概括
较高的甘油三糖 (TyG) 指数是胰岛素抵抗的标志物,与甲状腺功能低下等甲状腺疾病的风险增加有关,因性别和更年期状态而有所变化. 身体质量指数 (BMI) 可能会混或调解这种关系.
科学领域:
- 内分泌学 在内分泌学.
- 代谢疾病 代谢疾病
- 甲状腺学 甲状腺学
背景情况:
- 代谢性疾病与甲状腺疾病有共同的病理联系,通常涉及胰岛素抵抗.
- 三甘油-葡萄糖 (TyG) 指数作为胰岛素耐药性的实际指标.
- 了解胰岛素抵抗标志物与甲状腺健康之间的联系对于代谢和内分泌研究至关重要.
研究的目的:
- 调查甘油三糖指数 (TyG) 与甲状腺疾病患病率之间的关联.
- 探索TyG指数与甲状腺疾病关系中的潜在的性别特异性和更年期状态相关差异.
- 使用孟德尔随机化评估TyG指数和甲状腺刺激激素 (TSH) 水平之间的因果关系.
主要方法:
- 分析了TIDE研究中47710名受试者的数据.
- 按TyG指数四分位数和性别对甲状腺疾病患病率的分层划分.
- 逻辑和多重线性回归模型来评估相关性; 门德尔随机化 (MR) 来确定因果关系.
主要成果:
- 较高的TyG指数四分位数与男性和女性甲状腺疾病的患病率增加显著相关.
- 提升的TyG指数与TyG指数四分位数中亚临床甲状腺功能低下的风险更高相关,特别是在女性中.
- 在TyG指数和TSH水平之间观察到正线性相关性;MR表明了潜在的因果关系,被BMI混.
结论:
- 泰格指数与甲状腺功能低下症和亚临床甲状腺功能低下症有关,相关性因性别和更年期状况而异.
- 门德尔的随机化分析表明,基因影响的TyG指数和高TSH之间的因果关系是由BMI调解或混的.
- 这些发现强调了胰岛素抵抗,代谢健康和甲状腺功能之间的复杂关系.
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