相关实验视频

Updated: Jun 25, 2025

Oral Biofilm Sampling for Microbiome Analysis in Healthy Children

Oral Biofilm Sampling for Microbiome Analysis in Healthy Children

Published on: December 31, 2017

对肠道微生物组组成与五岁以下儿童发育迟缓之间的关联进行系统审查

Mwelwa Chibuye^1,2,3, Daniel R Mende^3,4, Rene Spijker¹

¹Department of Global Health, Amsterdam Institute for Global Health and Development (AIGHD), Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands.

NPJ biofilms and microbiomes

|May 23, 2024

概括

儿童发育迟缓与肠道细菌的改变有关,发育迟缓的儿童表现出更高的微生物多样性和引起炎症的微生物的增加. 这些肠道微生物组的变化可能在发育迟缓方面发挥作用.

科学领域:

微生物学微生物学
儿科儿科儿科
全球健康全球健康

背景情况:

儿童发育迟缓会影响认知发育,增加感染风险.
人们越来越认识到肠道微生物组在衰老的病原发生过程中的作用.

研究的目的:

在低收入和中等收入国家 (LMICs) 中,系统地审查和综合高通量肠道微生物组组成的高通量基因组数据,比较低收入和中等收入国家 (LMICs) 的5岁以下的不发育儿童.

主要方法:

使用高通量基因组测序的14项研究的系统审查和元合成.
肠道微生物组组成 (多样性和特定的种类/族群) 在缩和非缩儿童中的分析.

主要成果:

在α多样性上没有一致的差异;在一些研究中,在缩儿童中观察到更高的β多样性.
不一致的类级别关联;没有单一的属性普遍与衰老相关.
衰老与病原生物的增加 (例如,Escherichia/Shigella,Campylobacter) 和减少的酸盐生产者 (例如,Faecalibacterium) 相关,以及口腔的种群和改变的代谢途径.

结论:

与不衰弱的同龄人相比,衰弱的儿童表现出明显的肠道微生物模式.
这些微生物的变化,包括病原生物的丰富性和减少的有益细菌,可能会导致发育迟缓的病原体.
肠道微生物群中的特定代谢途径与线性生长和衰老有关.

更多相关视频

An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota

An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota

Published on: July 31, 2019

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

Published on: October 15, 2019

相关概念视频

Anatomy of the Intestines

Anatomy of the Intestines

Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...

What is Monogastric Digestion?

What is Monogastric Digestion?

The human body contains a monogastric digestive system. In a monogastric digestive system, the stomach only contains one chamber in which it digests food. Several other animal species also have monogastric digestive systems, including pigs, horses, dogs, and birds. This chapter, however, focuses on the human digestive system.