用支持载体机器,监管网络模型对中度性关节炎患者分层临床数据的表征,以及对关节炎倡议数据的验证
Maria Segarra-Queralt1, Mar Galofré1, Laura Tio2
1BCN MedTech, Department of Engineering, Universitat Pompeu Fabra, 08018, Barcelona, Spain.
Scientific reports
|May 23, 2024
概括
需要客观的生物标志物来诊断膝关节骨关节炎 (OA). 这项研究使用机器学习结合了临床和分子数据,确定了疼痛灾难性和瘦素作为更准确的关键指标,用于膝关节OA患者的分层.
科学领域:
- 生物标志物和诊断仪器
- 计算生物学是一种计算生物学.
- 骨关节炎的研究研究.
背景情况:
- 目前的膝关节骨关节炎 (OA) 诊断依赖于主观症状 (例如,WOMAC问卷),缺乏客观措施.
- 疼痛报告中的不一致以及关节外观和症状之间的差异需要客观的诊断生物标志物.
- 现有的诊断方法不能完全捕捉OA的复杂性,突出需要先进的分析方法.
研究的目的:
- 调查临床和分子数据之间的关系,以客观地诊断膝关节OA.
- 根据各种数据输入,开发和评估用于分层膝关节OA患者的分类模型.
- 确定影响OA诊断和进展的关键临床描述因素和分子因素.
主要方法:
- 在51名患有Kellgren-Lawrence 2-3级膝关节OA的女性队列中使用支持矢量机器 (SVM) 和调节网络模型.
- 使用的临床描述 (疼痛灾难性,抑郁,功能性等) ),突液蛋白质组数据 (25种蛋白质) 和转录因子激活作为输入特征.
- 应用了优化二元化值的Youden测试和用于分类器性能评估的ROC-AUC分析.
主要成果:
- 疼痛灾难主义成为最佳临床分类器 (AUC = 0.9),受功能性和疼痛敏感性的影响,这表明中国恐惧症的作用.
- 突液中的瘦素强烈影响了分类器,表明膝关节OA中低度炎症的意义.
- 功能性显示AUC为0.7,FOXO下调是关键因素,而转录因子分类器的性能有限 (平均AUC=0.608).
结论:
- SVM和监管网络模型的结合为客观膝关节OA患者分层提供了一个有希望的方法.
- 临床因素,如疼痛灾难性和分子因素,如瘦素,对于理解和诊断膝关节OA至关重要.
- 需要在更大的纵向队列中进行进一步的验证,以确认这些客观生物标志物和模型在临床实践中的有用性.
相关概念视频
01:09Functional Classification of Joints
4.0K
Functional Classification of Joints
The functional classification of joints is determined by the amount of mobility between the adjacent bones. Joints are functionally classified as a synarthrosis or immobile joint, an amphiarthrosis or slightly moveable joint, or as a diarthrosis, a freely moveable joint. Fibrous and cartilaginous joints can be functionally classified as either synarthroses or amphiarthroses, whereas all synovial joints are classified as diarthroses.
Synarthrosis
An...
The functional classification of joints is determined by the amount of mobility between the adjacent bones. Joints are functionally classified as a synarthrosis or immobile joint, an amphiarthrosis or slightly moveable joint, or as a diarthrosis, a freely moveable joint. Fibrous and cartilaginous joints can be functionally classified as either synarthroses or amphiarthroses, whereas all synovial joints are classified as diarthroses.
Synarthrosis
An...
4.0K
01:12Statistical Software for Data Analysis and Clinical Trials
534
Statistical software is pivotal in data analysis and clinical trials by providing tools to analyze data, draw conclusions, and make predictions. These software packages range from simple data management applications to complex analytical platforms, supporting various statistical tests, models, and simulation techniques. Their significance lies in their ability to handle vast amounts of data with precision and efficiency, enabling researchers to validate hypotheses, identify trends, and make...
534
00:59Model-Independent Approaches for Pharmacokinetic Data: Noncompartmental Analysis
60
Noncompartmental analyses offer an alternative method for describing drug pharmacokinetics without relying on a specific compartmental model. In this approach, the drug's pharmacokinetics are assumed to be linear, with the terminal phase log-linear. This assumption allows for simplified analysis and interpretation of the drug's behavior in the body.
One important characteristic of noncompartmental analyses is that drug exposure increases proportionally with increasing doses. This...
One important characteristic of noncompartmental analyses is that drug exposure increases proportionally with increasing doses. This...
60
01:17Classification of Illness
7.5K
The meaning of illness is individualized to each person who experiences an alteration in health. In contrast, disease is a medical term indicating a pathological change in the structure and function of the body or mind. It is a condition that has specific symptoms and boundaries.
An illness is a response to a disease in which the person's level of functioning is changed compared with a previous level. The general classification of illness includes acute and chronic.
Acute illness is severe...
An illness is a response to a disease in which the person's level of functioning is changed compared with a previous level. The general classification of illness includes acute and chronic.
Acute illness is severe...
7.5K
01:18Classification of Bones
5.4K
The bones of the human skeletal system are of varied shapes, sizes, and functions. They can be classified based on their shape and function into four major classes: long bones, short bones, flat bones, and irregular bones. Some classifications include a fifth type, the sesamoid bones, as a separate class, whereas others categorize them under short bones.
Long and Short Bones
The appendicular skeleton, particularly the upper and lower limbs, is primarily made of long and short bones. The...
Long and Short Bones
The appendicular skeleton, particularly the upper and lower limbs, is primarily made of long and short bones. The...
5.4K
01:20Structural Classification of Joints
3.3K
Joints, also known as articulations, are classified based on their structural characteristics, i.e., based on whether the articulating surfaces of the adjacent bones are directly connected by fibrous connective tissue or cartilage, or whether the articulating surfaces contact each other within a fluid-filled joint cavity. These differences serve to divide the joints of the body into three structural classifications.
A fibrous joint is where the adjacent bones are united by fibrous connective...
A fibrous joint is where the adjacent bones are united by fibrous connective...
3.3K