在ECHO队列联盟中,宿主因素与怀孕期间的阴道微生物组结构有关
Kimberly McKee1, Christine M Bassis2, Jonathan Golob2
1Department of Family Medicine, University of Michigan, 1018 Fuller St, Ann Arbor, MI, 48104, USA. kimckee@umich.edu.
Scientific reports
|May 23, 2024
概括
社会人口学因素在怀孕期间显著影响阴道微生物群. 较低的教育水平与特定的细菌社区状态有关,突出显示了它们在微生物组研究中的重要性.
科学领域:
- 微生物组研究的研究.
- 生殖健康 生殖健康
- 环境健康 环境健康
背景情况:
- 怀孕期间阴道微生物群的组成对母亲和婴儿的健康至关重要.
- 了解影响阴道微生物群结构的因素对于识别健康风险至关重要.
- 之前的研究已经探讨了各种宿主因素,但需要对多样化的队列进行全面分析.
研究的目的:
- 为了确定与怀孕期间阴道微生物群结构相关的临床和人口宿主因素.
- 评估不同种群中这些宿主因素的保护情况.
- 确定宿主因素对阴道社区状态类型 (CST) 的独立和联合影响.
主要方法:
- 分析了16SrRNA基因扩增序列的分析,这些序列来自从环境影响儿童健康结果 (ECHO) 计划中收集的阴道微生物群数据 (N=683).
- 应用PERMANOVA模型来评估与阴道社区结构相关的因素.
- 利用多项物流回归和随机森林模型来测试宿主因子对CST的影响,并确定特定的分类学特征.
主要成果:
- 人口和社会因素比临床因素解释了怀孕阴道微生物群的更多变化.
- 较低的教育水平是L. iners主导 (CST III) 和多样化 (CST IV) 状态的强有力的预测因素.
- 泌尿器官的病原体 (例如,Aerococcus christensenii,Gardnerella spp.) 已经存在. 和L. iners被确定为与宿主因素和社区不稳定性相关的关键分类特征.
结论:
- 社会人口学因素在怀孕期间与阴道微生物群结构密切相关.
- 这些因素应被视为人类微生物组研究中变异的重要来源.
- 这些发现强调了将健康的社会决定因素纳入微生物组研究的必要性,以全面了解怀孕结果.
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