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身体活动模式与帕金森病风险的关联

Fabin Lin^1,2,3,4, Yixiang Lin^1,2,3, Lina Chen^1,2,3

¹Department of Neurology, Center for Cognitive Neurology, Institute of Clinical Neurology, Fujian Medical University Union Hospital, 29 Xinquan Road, Fuzhou, 350001, China.

NPJ digital medicine

|May 23, 2024

概括

参与体育活动,无论是作为一个周末的战士还是定期的分配,显著降低了帕金森病的风险. 这两种运动模式在降低发展神经退行性疾病的可能性方面都同样有效.

科学领域:

神经科学和运动生理学
神经退行性疾病的流行病学

背景情况:

越来越多的证据将运动持续时间与帕金森病 (PD) 风险联系在一起.
缺乏高质量的前性数据,比较"周末战士" (WW) 与均等分布的运动模式及其对PD风险的影响.

研究的目的:

研究不同体力活动模式与患帕金森病的风险之间的关联.
为了比较WW运动模式的神经保护作用与定期分布的运动模式.

主要方法:

分析了89,400名英国生物库参与者的运动数据,这些参与者使用了手腕加速度计.
将参与者分为不活跃的,经常活跃的和WW运动组.
帕金森病风险的评估使用多因素考克斯模型,平均随访时间为12.32年.

主要成果:

活跃的WW和经常活跃的组都显示了与不活跃组相比,帕金森病的风险明显较低 (HR <0.58,P <0.001).
在活跃的WW组和经常活跃的组之间,在帕金森病风险上没有发现统计学上显著的差异 (HR = 0.77,P = 0.099).
在随访期间,诊断出329例帕金森病.

结论:

周末战士和定期分配的运动模式在降低帕金森病风险方面同样有效.
满足世卫组织每周150分钟的中度至强度体力活动的建议,无论分布模式如何,都能显著地保护神经系统免受帕金森病的影响.

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