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Updated: Jun 25, 2025

Detecting Somatic Genetic Alterations in Tumor Specimens by Exon Capture and Massively Parallel Sequencing
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从RNA测序数据中发现人体突变的泛癌发现

Gongyu Tang1,2, Xinyi Liu1, Minsu Cho1

  • 1Department of Pharmacology and Regenerative Medicine, University of Illinois at Chicago, Chicago, IL, USA.

Communications biology
|May 23, 2024
PubMed
概括

研究人员使用来自癌症基因组图谱 (TCGA) 的RNA测序数据确定了超过105,000种新的体内突变 (SM). 这一发现提高了对癌症基因组的理解,并有助于开发向疗法.

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相关概念视频

RNA-seq03:21

RNA-seq

RNA sequencing, or RNA-Seq, is a high-throughput sequencing technology used to study the transcriptome of a cell. Transcriptomics helps to interpret the functional elements of a genome and identify the molecular constituents of an organism. Additionally, it also helps in understanding the development of an organism and the occurrence of diseases. 
Before the discovery of RNA-seq, microarray-based methods and Sanger sequencing were used for transcriptome analysis. However, while...
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