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Updated: Jun 25, 2025

Techniques to Induce and Quantify Cellular Senescence
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Techniques to Induce and Quantify Cellular Senescence

Published on: May 1, 2017

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p21CIP1-CDK4-DREAM轴是基因毒性压力诱导的细胞衰老的主调节器

Ariane Schmidt1, Sebastian Allmann1, Christian Schwarzenbach1

  • 1Department of Toxicology, University Medical Center of the Johannes Gutenberg University of Mainz, Obere Zahlbacher Str. 67, D-55131 Mainz, Germany.

Nucleic acids research
|May 23, 2024
PubMed
概括

由DNA损伤驱动的细胞衰老是由p21CIP1,CDK4和DREAM复合体调节的. 这一途径使增殖因子沉默,控制基因毒性压力诱导的衰老.

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