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Updated: Jun 25, 2025

A Real-time Potency Assay for Chimeric Antigen Receptor T Cells Targeting Solid and Hematological Cancer Cells
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A Real-time Potency Assay for Chimeric Antigen Receptor T Cells Targeting Solid and Hematological Cancer Cells

Published on: November 12, 2019

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针对BCMA/CD47的通用CAR-T细胞在多发性骨髓瘤中表现出卓越的抗瘤活性

Qizhong Lu1, Hexian Li1, Zhiguo Wu1

  • 1Department of Biotherapy, State Key Laboratory of Biotherapy and Cancer Center, Research Unit of Gene and Immunotherapy, Chinese Academy of Medical Sciences, Collaborative Innovation Center of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, China.

Journal of nanobiotechnology
|May 23, 2024
PubMed
概括

研究人员开发了新的BCMA/CD47导向的通用CAR-T (UCAR-T) 细胞,以克服对多发性骨髓瘤自主CAR-T治疗的局限性. 这些UCAR-T细胞在体外和体内表现出强大的抗髓瘤活性,提供了一个有前途的"现成"免疫疗法策略.

关键词:
免疫治疗是一种免疫疗法.多发性骨髓瘤是一种多发性骨髓瘤.一个纳米人体.全面的仿制抗原受体是仿制抗原受体.

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