在高强度运动挑战后,肠道屏障和免疫功能的各种标志物之间的关联
Maria Fernanda Roca Rubio1, Mattias Folkesson2, Carolin Kremp1
1Nutrition-Gut-Brain Interactions Research Centre, School of Medical Sciences, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.
Physiological reports
|May 24, 2024
概括
剧烈的运动增加了肠道的透性,并改变了免疫标志物. 尿酸可能会保护肠道屏障,而炎症会影响身体疲劳.
科学领域:
- 运动生理学 运动生理学
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
背景情况:
- 剧烈的运动可能会损害肠道屏障功能,导致胃肠道问题.
- 对于运动员来说,了解运动引起的肠透性的系统影响至关重要.
研究的目的:
- 为了探索高强度运动后肠道透性增加的全身影响.
- 调查肠道屏障标记物,免疫反应和感知到的劳动力之间的相关性.
主要方法:
- 41名耐力训练运动员进行了60分钟的高强度跑步机跑步 (80%的VO2max).
- 小肠透性通过尿液中乳糖/拉姆诺斯 (L/R) 的比率进行评估.
- 血液,唾液和便样本被分析为肠道屏障,免疫和氧化应激生物标志物.
主要成果:
- 高强度运动提高了肠道屏障破坏,免疫激活和氧化应激的标志物.
- 在L/R比和尿酸水平之间观察到负相关性.
- 在男性中,L/R比和便染色素A之间发现了正相关性.
- 感知到的劳动力与中白素-6 (IL-6),中白素-10 (IL-10) 和唾液皮质醇水平相关.
结论:
- 剧烈的运动显著影响肠道透性和全身炎症标志物.
- 尿酸可能具有对运动诱导的肠道透性的屏障保护作用.
- 炎症过程与强度炼后体验的身体疲劳有关.
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