相关实验视频

Updated: Jun 25, 2025

Genome-wide RNAi Screening to Identify Host Factors That Modulate Oncolytic Virus Therapy

Genome-wide RNAi Screening to Identify Host Factors That Modulate Oncolytic Virus Therapy

Published on: April 3, 2018

使用全基因组CRISPR查识别参与瘤性病毒治疗的限制性分子

Yiye Zhong¹, Huangying Le¹, Xue Zhang¹

¹Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, 200240, China.

Journal of hematology & oncology

|May 24, 2024

概括

工程化瘤性病毒 (OVs) 对质母细胞瘤和三阴性乳腺癌的安全性和有效性得到了提高. 将OV与PARP抑制剂和免疫检查点抑制剂相结合,可以改善瘤特异性免疫反应和生存率.

科学领域:

瘤治疗性病毒疗法
癌症免疫疗法癌症免疫疗法
分子瘤学分子瘤学

背景情况:

瘤病毒 (OV) 是有前途的癌症治疗药物,但在有效性和安全性方面面临限制.
使用神经元特异性microRNA-124和GM-CSF的工程OV可以提高神经元安全性,而不会显著影响病毒复制.
通过全基因组CRISPR查,PARP1被确定为HSV-1限制因子.

关键词:

通过CRISPR查进行查.组合疗法是一种联合疗法.瘤学病毒病毒.PARP1 的第一部分.在PD-1中使用PD-1.

更多相关视频

Genome-Wide CRISPR Screen for Unveiling Radiosensitive and Radioresistant Genes

Genome-Wide CRISPR Screen for Unveiling Radiosensitive and Radioresistant Genes

Published on: May 23, 2025

Pooled CRISPR-Based Genetic Screens in Mammalian Cells

Pooled CRISPR-Based Genetic Screens in Mammalian Cells

Published on: September 4, 2019

相关概念视频

CRISPR

CRISPR

Genome editing technologies allow scientists to modify an organism’s DNA via the addition, removal, or rearrangement of genetic material at specific genomic locations. These types of techniques could potentially be used to cure genetic disorders such as hemophilia and sickle cell anemia. One popular and widely used DNA-editing research tool that could lead to safe and effective cures for genetic disorders is the CRISPR-Cas9 system. CRISPR-Cas9 stands for Clustered Regularly Interspaced...

CRISPR and crRNAs

CRISPR and crRNAs

Bacteria and archaea are susceptible to viral infections just like eukaryotes; therefore, they have developed a unique adaptive immune system to protect themselves. Clustered regularly interspaced short palindromic repeats and CRISPR-associated proteins (CRISPR-Cas) are present in more than 45% of known bacteria and 90% of known archaea.
The CRISPR-Cas system stores a copy of foreign DNA in the host genome and uses it to identify the foreign DNA upon reinfection. CRISPR-Cas has three different...