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花生口服免疫疗法使用大量加热和烤花生新成分
Mona I Kidon1,2,3, Ronen Shavit1,2, Yael Levy4
1Clinical Immunology, Angioedema and Allergy Unit, Center for Autoimmune Diseases, Sheba Medical Center, Tel Hashomer, Israel.
概括
使用热处理的化花生蛋白-MH (LPP-MH) 的口服免疫疗法是对儿童花生过敏的安全有效治疗方法. 这种方法使得高度过敏的儿童可以在没有严重反应的情况下食用大量的花生蛋白.
科学领域:
- 过敏和免疫学 过敏和免疫学
- 儿科胃肠病学 儿科胃肠病学
- 食品科学 食品科学 食品科学
背景情况:
- 口服免疫疗法 (OIT) 是对儿童花生过敏 (PA) 的可行的治疗方法,但通常会引起副作用.
- 标准的花生蛋白质具有耐热性,限制了它们在低过敏性食品中的使用.
- 软化花生蛋白-MH (LPP-MH) 是一种新的花生成分,可以通过加热使其变得不那么过敏.
研究的目的:
- 为了评估OIT的安全性和有效性,使用广泛加热和烤 (EHEB) LPP-MH在患有PA的儿童中.
- 为了确定EHEB LPP-MH是否可以足够地减少花生过敏性,OIT.
主要方法:
- 一项试点研究涉及33名患有PA的儿童,他们接受了40周的OIT协议,每天摄入300毫克热处理的LPP-MH.
- 花生食物挑战是在治疗后和6-12个月的随访期间进行的.
主要成果:
- 在40周后,32/33名儿童容忍超过300毫克的天然花生蛋白,平均累积耐受剂量 (MCTD) 显著增加.
- 在挑战或家庭治疗期间没有观察到需要上腺素的严重过敏反应.
- 在6-12个月的维护期,MCTD达到8821毫克,允许大多数儿童适合年龄的食中加入花生.
结论:
- 用热处理LPP-MH的OIT似乎是一种安全有效的方法来治疗儿童的PA.
- 这种新的OIT方法使得高度过敏的个体可以通过饮食消费花生蛋白.
- 通过随机对照试验进行进一步验证是必要的.
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