在高温的日子里,对他类药物的坚持和全因死亡率
Gabriel Chodick1,2, Ran S Rotem2,3, Todd A Miano4
1School of Public Health, Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
Pharmacoepidemiology and drug safety
|May 24, 2024
概括
对他类药物治疗的高度坚持可能会降低在极热天的死亡风险,尤其对男性来说. 这一发现支持了在热浪期间他类药物的潜在热保护作用.
科学领域:
- 心血管医学 心血管医学
- 环境健康 环境健康
- 药理学 药理学是指药理学的学科.
背景情况:
- 类药物是被广泛处方的降胆固醇药物.
- 新出现的证据表明,他类药物可能会对与热相关的死亡率提供保护.
- 在极端炎热期间,他类药物对死亡率的影响需要进一步调查.
研究的目的:
- 调查在炎热的日子里,他类药物坚持和全因死亡率之间的关联.
- 为了确定使用他类药物是否会产生热保护作用.
主要方法:
- 一个历史性的新用户队列研究以色列229,918个人 (1998-2006).
- 通过覆盖日数 (PDC) 的比例来衡量他类药物的坚持.
- 炎热天 (≥39°C) 的全因死亡率是主要结局.
主要成果:
- 在极热天 (HR 0.85; 0.72-1.00) 上,他类药物PDC增加10%与死亡风险降低有关.
- 这种效应在男性 (HR 0.66;0.45-0.95) 与女性 (HR 0.98;0.78-1.23) 相比更为明显.
- 在寒冷的日子里没有观察到任何显著的关联.
结论:
- 斯坦丁固守可能与极端高温事件中的死亡率降低有关.
- 在男性中,他类药物的热保护作用似乎更为显著.
- 这些发现支持他类药物在减轻与热有关的健康风险方面的作用.
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