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Updated: Jun 25, 2025

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HPTN 083-02:在注射PrEP研究中影响注射PrEP坚持和保留的因素
Christina Psaros1,2, Georgia R Goodman1,3, Jasper S Lee1
1Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts, USA.
Journal of the International AIDS Society
|May 24, 2024
概括
长效注射性卡博特格拉维尔 (CAB-LA) 是男性与男性发生性关系的男性和与男性发生性关系的跨性别女性的优越艾滋病毒预防方法. 注射性暴露前预防 (PrEP) 的积极经验与灵活的诊所环境和支持性工作人员有关.
科学领域:
- 艾滋病毒预防研究 预防研究
- 可以注射的暴露前预防 (PrEP)
- 质量健康研究 质量健康研究
背景情况:
- 在与男性发生性关系的男性和与男性发生性关系的跨性别女性中,HPTN 083试验证实长效卡博特格拉维尔 (CAB-LA) 优于每日口服埃姆特里西塔宾/特诺福维尔二氧化 fumarate (TDF/FTC) 用于PrEP.
- 该试验提供了一个独特的机会来探索参与者与注射PrEP的经验.
研究的目的:
- 在HPTN 083试验中对可注射PrEP的参与者体验进行定性探索.
- 确定促进注射PrEP的坚持和实施的促进者和障碍.
主要方法:
- 对来自美国和巴西的40名参与者进行了定性个人访谈.
- 参与者根据坚持水平 (坚持,不坚持,早期停药者) 进行了抽样.
- 采访是在2019年11月至2020年3月之间进行的,这是在研究解盲之前进行的,并使用内容分析进行分析.
主要成果:
- 参与者报告了可注射PrEP的积极经验,认为它是一种提高福祉和为社区研究做出贡献的手段.
- 遵守的促进者包括灵活的安排,彻底的沟通,非判断性咨询和肯定性临床环境.
- 障碍包括结构因素 (例如,财务限制,旅行) 和竞争需求 (例如,工作时间表). 注射部位的经验通常是积极的,带有最小的不适.
结论:
- 参与注射PrEP试验被认为是积极的,提高了参与者的幸福感.
- 灵活的研究场所和肯定,非判断性的临床环境对于遵守至关重要.
- 未来的干预措施应解决结构性障碍,并提供灵活的输送方法,以支持持续使用注射PrEP.
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