从分子变异到行为适应:揭示灵长类动物氧化系统中的适应性表观症
Pedro Vargas-Pinilla1,2, Bibiana S Oliveira Fam1,3, Gustavo Medina Tavares1
1Laboratory of Human and Molecular Evolution, Departamento de Genética, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
American journal of biological anthropology
|May 24, 2024
概括
我们在灵长类动物中发现了新的催产素 (OT) 结合基因 (AAMEN,VAMEN),揭示了它们与OT和受体的共同进化. 这说明了社会行为和家长照顾的适应性.
科学领域:
- 进化生物学 进化生物学
- 分子生物学分子生物学
- 灵长类动物遗传学
背景情况:
- 催产素系统在哺乳动物的社会行为和繁殖中起着至关重要的作用.
- 像氧化酶 (LNPEP) 这样的蛋白质中保存的基因对于蛋白质功能和进化研究至关重要.
研究的目的:
- 研究灵长类动物LNPEP氧化酶中的催产素 (OT) 和GAMEN结合动机的变异性.
- 探索与灵长类繁殖特征有关的LNPEP动机,OT和催产素受体 (OTR) 之间的进化关系.
主要方法:
- 测序LNPEP基因段的序列,其中包含GAMEN基因在34种Platyrrhini物种和OT基因在21种物种中.
- 使用公共数据库来获取额外的灵长类LNPEP,OT和OTR序列.
- 进行进化和共同进化的分析,包括与表型特征相关的氨基酸的宏观进化和结合能量的计算.
主要成果:
- 鉴定了两种新的LNPEP图案,AAMEN和VAMEN,扩大了胎盘哺乳动物中已知的图案多样性.
- 证明GAMEN,AAMEN和VAMEN动图及其相应的OT和OTR分子之间的共同进化相关性.
- 在 Callithrix jacchus VAMEN 和 Pro extsuperscript{8}OT 之间观察到较高的结合能,与人类的正经相比.
结论:
- 新的AAMEN和VAMEN图案与OT和OTR的共同进化表明,与灵长类动物特定的生殖和社会行为存在功能联系.
- 这些发现突显了灵长类动物中催化素作用系统的适应意义,这种适应意义是由特定类别的氨基酸共同进化驱动的.
- 这项研究提出了催化素系统作为一种适应性表观学谱,影响了灵长类动物的父亲照顾,一夫一妻制和 litter 尺寸等特征.
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