抗痴呆药物使用者的使用趋势和特征:一项基于人口的大型跨国网络研究
Carlen Reyes1,2, Danielle Newby3, Berta Raventós1,4
1Fundació Institut Universitari per a la recerca a l'Atenció Primària de Salut Jordi Gol i Gurina (IDIAPJGol), Barcelona, Spain.
Age and ageing
|May 24, 2024
概括
在老年痴呆症患者中使用抗痴呆药物 (ADD) 显示出不同国家的不同趋势. 西班牙和荷兰的发病率显著下降,而英国则出现波动,突显了需要一致的药理管理的需要.
科学领域:
- 神经学 神经学
- 药理学 药理学是指药理学的学科.
- 公共卫生 公共卫生
背景情况:
- 目前对抗痴呆症药物 (ADD) 的时间趋势分析有限.
- 现实世界的数据对于了解痴呆症患者的ADD发病率至关重要.
研究的目的:
- 评估痴呆症患者中抗痴呆药物 (ADD) 的发生率 (IR).
- 利用来自多个国家的真实世界数据分析ADD处方的时间趋势.
主要方法:
- 使用来自英国 (CPRD-GOLD),西班牙 (SIDIAP) 和荷兰 (IPCI) 的初级保健数据,采用了一个队列研究设计.
- 数据涵盖2007/2008年至2020年,包括40岁以上的患者,至少有一年以前的数据.
- 作为主要结局,对rivastigmine,galantamine,donepezil或memantine的事件处方,并随访直到研究结束或特定事件.
主要成果:
- 英国的ADD发病率出现波动,从2007年到2010年下降,然后增加到2019年,并在2020年再次下降.
- 西班牙和荷兰的ADD发病率分别下降了72%和77%,从各自的开始年到2020年.
- 65-79岁的个人和男性在英国和荷兰更有可能发病.
结论:
- 痴呆症的药理管理仍然具有高度的变化.
- 迫切需要在痴呆症患者的药物治疗方面达成更大的共识.
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