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Updated: Jun 25, 2025

A Nonviral Approach to Generate Transient Chimeric Antigen Receptor T Cells Using mRNA for Cancer Immunotherapy
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[mRNA纳米输送系统在CAR-T瘤免疫疗法中的应用]

Yi Zeng1, Shiyao Wei1, Jianhong Sun1

  • 1College of Life Sciences and Health, Wuhan University of Science and Technology, Wuhan 430065, Hubei, China.

Sheng wu gong cheng xue bao = Chinese journal of biotechnology
|May 24, 2024
PubMed
概括

使者RNA (mRNA) 纳米传递系统在CAR-T癌症免疫疗法方面表现有前途. 这些系统可以直接向T细胞或抗原呈现细胞,以增强抗瘤免疫反应.

关键词:
仿真抗原受体T细胞 (CAR-T) 是一种在体外转录mRNA.纳米输送系统的纳米输送系统.瘤免疫疗法 免疫疗法

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Tumor Immunotherapy01:27

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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