生物衍生单体的持续合成的过程强化,用于可持续的涂料使用泰勒流反应器的流动反应器
Matthew D Edwards1, Matthew T Pratley1, Charles M Gordon2
1School of Chemistry, University of Nottingham, University Park, Nottingham NG7 2RD, U.K.
Organic process research & development
|May 24, 2024
概括
我们优化并扩大了生物衍生性氧丁化物单体的两步合成,这是烯酸涂料的潜在替代品. 这种精简的工艺避免了中间隔离,实现了可持续化学制造的高产量和生产率.
科学领域:
- 化学工程是化学工程的重要组成部分.
- 有机合成 有机合成
- 可持续化学 可持续化学
背景情况:
- 生物衍生性醇基烯化物单体被研究为传统烯酸基涂料的可持续替代品.
- 之前的合成涉及一个多步骤的批量过程,反应时间长,中间隔离.
研究的目的:
- 为了优化和扩大阿尔科西布丁化物单体的两步合成.
- 为了望远镜,氧化和凝结步骤成为一个单一的,高效的过程.
- 开发这些生物衍生单体的千克级生产方法.
主要方法:
- 利用富里埃变换红外光谱 (FTIR) 来实时监测反应和进行二维相关性分析.
- 采用半连续光反应器 (改造的旋转蒸发器) 和连续的泰勒旋光反应器进行光氧化.
- 使用超热甲醇实现了压缩热流反应器用于凝结步骤.
主要成果:
- 通过望远镜成功完成了两个反应步骤,消除了中间隔离,并使千克级生产成为可能.
- 使用泰勒旋光反应器,实现了光氧化步骤的85%产量,预计生产率为1.3公斤/天.
- 使用流量反应器,将热凝结反应时间从20小时缩短到不到1分钟,达到每天700g以上的生产率.
- 确立了methoxybutenolide单体的67%的整体两步产量.
结论:
- 开发了一种高效,可扩展和可望远镜处理的工艺,用于生产生物衍生型的氧丁化单体.
- 证明了连续流反应堆和在线FTIR监控的有效性,以优化过程和扩大规模.
- 这种优化合成为先进涂料的单体提供了一个可持续和工业上可行的途径.
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