肠道微生物群-代谢物相互作用反映了饮食模式对早熟青春期的影响
Ying Wang1,2, Chuandi Jin3,4, Hongying Li1,2
1Children's Hospital Affiliated to Shandong University, Shandong University, Jinan 250022, China.
iScience
|May 24, 2024
概括
饮食,肠道细菌和代谢物影响过早的青春期. 特定的肠道微生物和代谢物可以帮助诊断早期青春期 (PP) 并影响其发展.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 微生物组研究 微生物组研究
- 代谢学 代谢学 代谢学
背景情况:
- 早期青春期 (PP),包括中央 (CPP) 和外围 (PPP) 形式,是一种儿科内分泌疾病.
- 饮食,肠道微生物群和代谢物都与PP有关,但潜在的机制尚未完全理解.
研究的目的:
- 研究肠道微生物群和代谢物在早期青春期的发展和分类中的特定作用.
- 探索结合微生物群和代谢物概况用于早期青春期的诊断潜力.
主要方法:
- 对肠道微生物群组成的分析,重点关注α多样性和短链脂肪酸 (SCFA) 生产细菌.
- 测量激素水平,包括黄素化激素 (LH),卵泡刺激激素 (FSH) 和雌激素.
- 研究特定细菌 (如Prevotella) 属,代谢物,饮食因素 (复杂碳水化合物,海鲜) 和与肥胖有关的细菌之间的相互作用.
主要成果:
- 增加的α多样性和SCFA产生细菌与升高的LH和FSH相关,有助于早期青春期.
- 一个由复杂碳水化合物影响的Prevotella控制的因子,降低了雌激素水平.
- 通过与肥胖相关的细菌和代谢物介导的海鲜消费降低了LH,降低了肥胖引起的PP风险和PPP到CPP进展.
结论:
- 肠道微生物群和代谢物概况有可能用于诊断早期青春期.
- 饮食因素与肠道微生物群相互作用,影响荷尔蒙水平和早期青春期的发展/进展.
- 研究结果提供了关于饮食,微生物组和早期青春期代谢物的复杂相互作用的见解.
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