在第三级护理机构的患者中,抗菌素耐药性和 Clostridium difficile 的相关风险因素
Murad A Mubaraki1, Mubbashir Hussain2, Faaiz Ul Hassan2
1Clinical Laboratory Sciences Department, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia.
Journal of tropical medicine
|May 24, 2024
概括
在巴基斯坦的医院中,Clostridium difficile (C. diff) 的抗菌耐药性很高,对常见的抗生素具有显著的耐药性. 这突出了C.diff作为一种关键的医院感染,需要更新的控制策略.
科学领域:
- 传染性疾病 传染性疾病
- 微生物学 微生物学
- 临床医学 临床医学
背景情况:
- 困难杆菌感染 (CDI) 是医院获得的腹的一个重要原因.
- 新兴的病原体和抗微生物药物耐药性对全球健康构成挑战.
- 第三级护理机构需要对耐药生物体进行持续监测.
研究的目的:
- 为了确定Clostridium difficile的发病率和抗菌素耐药性模式.
- 为了确定与巴基斯坦CDI相关的风险因素.
- 为CDI提供治疗和控制策略的信息.
主要方法:
- 从2019年1月到2020年12月进行了一项前性横截面研究.
- 分析了来自住院腹患者的450个便样本.
- 进行了培养,ELISA,PCR和抗菌敏感性测试.
主要成果:
- 在培养的便样本中,24%的便样本中检测到困难菌.
- 观察到高抗微生物药物耐药率,其中90.7%的分离物对至少一种抗生素有耐药性.
- 对青素 (83.3%),阿莫西西林 (70%) 和纳利迪克酸 (61%) 发现了显著的耐药性.
- 范科米辛 (6.4%) 和艾米皮涅姆 (3.7%) 的抗药率是最低的.
- CDI与年龄增加,抗生素使用,手术,PPI和并发症有显著的相关性.
结论:
- 困难杆菌感染是巴基斯坦佩沙瓦的一个普遍的医院感染.
- 高抗微生物耐药性需要修订治疗和预防方案.
- 进一步的研究和监测对于有效管理CDI至关重要.
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