饮食中的脂肪酸调节了对空气污染的氧化应激反应,但不是对感染的反应
Ann-Kathrin Ziegler1, Johan Kjellberg Jensen1,2, Lucía Jiménez-Gallardo3
1Department of Biology, Lund University, Lund, Sweden.
Frontiers in physiology
|May 24, 2024
概括
暴露于臭氧和人类食物来源等污染物的野生动物面临着增加的氧化应激. 饮食和感染也会影响这种情况,但它们对鸟类健康的影响是复杂的,可能不会累积.
科学领域:
- 环境毒理学环境毒理学
- 野生动物生态生理学
- 氧化应激研究研究 氧化应激研究
背景情况:
- 人类造成的环境变化使野生动物暴露在诸如热层臭氧等污染物中,热层臭氧是一种强有力的亲氧化剂.
- 人类活动改变野生动物的食物供应和病原体分布,可能与污染物相互作用.
- 饮食中的多不和脂肪酸 (PUFA),特别是omega-6与omega-3的比例,会影响炎症和氧化应激反应.
研究的目的:
- 为了研究饮食中的omega-6:omega-3 PUFA比率如何调节暴露于臭氧的鸟类中的氧化应激.
- 为了确定臭氧,饮食和模拟感染对野生动物氧化还原平衡的相互作用影响.
- 评估这些联合压力因素对鸟类抗氧化能力和氧化损伤的影响.
主要方法:
- 一个全因子实验,使用受囚禁的斑马 (Taeniopygia guttata) 暴露于操纵的饮食omega-6:omega-3比率和臭氧水平.
- 通过注射脂聚糖胺来模拟感染,以触发免疫反应和氧化突发.
- 测量抗氧化剂状态 (GSH/GSSG比,总氨酸) 和抗氧化能力 (OXY).
主要成果:
- 臭氧暴露抵消了对抗氧化剂比率 (GSH/GSSG) 的饮食特异性影响,同时整体降低了总谷 (tGSH).
- 富含omega-6的饮食中的鸟类与富含omega-3的饮食中的鸟类相比,表现出更高的抗氧化能力 (OXY).
- 只有免疫挑战显著增加了氧化损伤,超过了饮食和臭氧对这个生物标志物的影响.
结论:
- 臭氧,食中的PUFAs和感染独立地影响鸟类的氧化还原系统,但它们的影响是脱的,对测量的生物标志物没有累积影响.
- 尽管缺乏累积效应,但这些压力因素的综合影响可能会降低野生鸟类的整体细胞功能.
- 了解这些复杂的相互作用对于预测人类改变环境中的野生动物健康至关重要.
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