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Updated: Jun 25, 2025

A Pipeline to Investigate the Structures and Signaling Pathways of Sphingosine 1-Phosphate Receptors
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具有PDE稳定的2'3'-cGAMP类似物,含有5'-S-基结,作为STING激动剂

Simpa K Yeboah1,2, Herman O Sintim1,2,3

  • 1Department of Chemistry 560 Oval Drive West Lafayette Indiana 47907-2084 USA.

RSC medicinal chemistry
|May 24, 2024
PubMed
概括

针对STING (干扰素基因刺激剂) 的新型循环二核酸相似物为癌症免疫治疗提供了增强的稳定性. 这些内分-S-酸化合物避免了二聚体问题,并保持了免疫刺激活性.

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