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识别马匹马作为Leptospira的病原性物种的储宿主

Camila Hamond^1,2, Emma N Adam³, Nathan E Stone⁴

¹National Veterinary Services Laboratories, Animal and Plant Health Inspection Service, U.S. Department of Agriculture, Ames, IA, United States.

Frontiers in veterinary science

|May 24, 2024

概括

马可以是无症状的马类白病的携带者,在它们的尿液中排出病原性白病菌. 这项研究在美国马匹中发现了多种不同的Leptospira物种,包括一种新型的血清细胞,这对于开发有效的疫苗和诊断至关重要.

科学领域:

兽医微生物学兽医微生物学
传染性疾病传染性疾病
动物健康动物健康

背景情况:

马匹白病会导致严重的生殖损失,并可以在马匹中建立无症状的载体状态.
了解流通的LeptoSpira物种的多样性对于疾病控制和预防至关重要.

研究的目的:

调查美国无症状马产生的致病性Leptospira的流行率和物种.
描述不同Leptospira菌株的毒性和脂多糖 (LPS) 概况.

主要方法:

聚合酶连锁反应 (PCR) 和细菌培养以检测尿液中的Leptospira.
微观凝结试验 (MAT) 用于血清学分析.
在仓鼠模型中的病毒性研究和LPS分析.

主要成果:

在37只无症状母马中,有3只PCR检测结果为病原性Leptospira阳性;一只PCR检测结果为*L. kirschneri*血清组Australis血清Rushan. kirschneri*血清组的培养结果阳性.
进一步的分析确定了其他无症状母马中的*L. kirschneri*血清组Australis和*L. interrogans*血清组Icterohaemorrhagiae.
一只堕胎的马匹有一个高的MAT标位到*L. interrogans*血清组Pomona.
携带和堕胎相关的菌株之间,病毒性和LPS概况有所不同.

结论:

美国的马匹作为各种病原性LeptoSpira物种的储存宿主,通过尿液排出它们.
在美国检测到*L. kirschneri*血清组Australis血清器Rushan是一个新的发现.
毒性和LPS的菌株特异性差异对于理解疾病病原和疫苗开发很重要.

关键词:

澳大利亚人 (Australis)莱普托斯皮拉 (Leptospira) 是一个类动物.马类的马类动物.吉尔什内里亚人吉尔什内利人莱普托斯皮罗斯症是什么?

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