在关节和相关疾病中的三体体感应
Sienna K Perry1, Joshua J Emrick1
1Department of Biologic and Materials Sciences & Prosthodontics, School of Dentistry, University of Michigan, Ann Arbor, MI, United States.
Frontiers in pain research (Lausanne, Switzerland)
|May 24, 2024
概括
了解关节 (TMJ) 的感觉神经对于治疗关节疾病 (TMD) 至关重要. 定义TMJ内置可能会导致更好的缓解疼痛和治疗慢性下疼痛.
科学领域:
- 神经科学是一个神经科学.
- 人体解剖学 解剖学 解剖学
- 疼痛研究 疼痛研究
背景情况:
- 关节 (TMJ) 通过协调骨,软骨,肌肉和带功能来促进食.
- 三神经 (CNV) 的内化提供了对生存至关重要的体感 (触觉,温度,自身感知,疼痛).
- 关节的特定体感内还没有很好地定义,这阻碍了对关节疾病 (TMD) 的理解.
研究的目的:
- 定义关节 (TMJ) 和相关组织的感觉内化.
- 调查外周内化在TMD相关慢性疼痛的发展中的作用.
- 确定改善止痛药和TMD治疗的潜在目标.
主要方法:
- 肌肉学检查TMJ组织以确定神经分布.
- 神经解剖学追踪技术用于绘制感官路径.
- 对体感神经元活动的分析,以应对TMJ刺激 (详情未提供摘要).
主要成果:
- 关节的体感内置仍然定义不佳.
- 像面部疼痛,头痛和耳这样的TMD症状与 nociceptor激活有关.
- 目前的TMD治疗只能暂时缓解症状.
结论:
- 需要详细了解TMJ感官内置.
- 专注于外围内置在慢性疼痛中的作用可以阐明TMD的起源.
- 这项研究可能有助于开发新的疼痛管理策略和改进的TMD疗法.
相关概念视频
Cranial Nerves: Types Part I
2.6K
Cranial nerves are responsible for transmitting motor and sensory information between the brain and various parts of the body. There are twelve pairs of cranial nerves, with the first six being essential in sensory perception, motor control, and autonomic functions related to the head and neck.
Olfactory Nerve (Cranial Nerve I)
The olfactory nerve, or cranial nerve I, is unique as it is purely sensory and dedicated to the sense of smell. This nerve originates in the olfactory epithelium of the...
Olfactory Nerve (Cranial Nerve I)
The olfactory nerve, or cranial nerve I, is unique as it is purely sensory and dedicated to the sense of smell. This nerve originates in the olfactory epithelium of the...
2.6K
Thermosensation
30.4K
Peripheral thermosensation is the perception of external temperature. A change in temperature (on the surface of the skin and other tissues) is detected by a family of temperature-sensitive ion channels called Transient Receptor Potential, or TRP, receptors. These receptors are located on free nerve endings. Those detecting cold temperatures are closer to the surface of the skin than the nerve endings detecting warmth. These thermoTRP channels, while temperature selective, have relatively...
30.4K
Somatosensation
36.6K
The somatosensory system relays sensory information from the skin, mucous membranes, limbs, and joints. Somatosensation is more familiarly known as the sense of touch. A typical somatosensory pathway includes three types of long neurons: primary, secondary, and tertiary. Primary neurons have cell bodies located near the spinal cord in groups of neurons called dorsal root ganglia. The sensory neurons of ganglia innervate designated areas of skin called dermatomes.
36.6K
Major Somatic Sensory Pathways
943
Sensory impulses related to touch, pressure, vibration, and proprioception from various body parts, such as the limbs, trunk, neck, and posterior head, travel to the cerebral cortex through the posterior column-medial lemniscus pathway. The pathway’s name derives from the two white-matter tracts that convey the impulses: the spinal cord's posterior column and the brainstem's medial lemniscus. First-order sensory neurons extend their axons into the spinal cord, forming the...
943
Sensory Perception: Organization of the Somatosensory System
2.9K
The somatosensory system is the central and peripheral nervous system component that senses and processes touch, pressure, pain, temperature, and body position or proprioception. The process of sensation takes place at three levels:
The receptor level:
The receptor level is the first stage of sensation. It involves the detection of a stimulus by specialized sensory receptors. The stimulus must arrive within the receptor's receptive field. Next, the receptor converts the energy of the...
The receptor level:
The receptor level is the first stage of sensation. It involves the detection of a stimulus by specialized sensory receptors. The stimulus must arrive within the receptor's receptive field. Next, the receptor converts the energy of the...
2.9K
Overview of Somatic Sensory Pathways
4.4K
Somatic sensory or somatosensory pathways refer to the neural pathways that carry information related to touch, pressure, pain, temperature, and proprioception from the skin, muscles, tendons, and joints to the brain. These pathways involve several stages of processing and integration of sensory information.
The somatosensory system is divided into three main pathways: the dorsal (or posterior) column-medial lemniscus, spinothalamic (or anterolateral), and spinocerebellar pathways.
The dorsal...
The somatosensory system is divided into three main pathways: the dorsal (or posterior) column-medial lemniscus, spinothalamic (or anterolateral), and spinocerebellar pathways.
The dorsal...
4.4K


