豆补充剂不会影响成年人血清腺素素水平:随机对照试验的系统审查和元分析
Jahangir Karimian1, Parivash Shekarchizadeh-Esfahani1
1Department of General Courses, School of Management and Medical Information Sciences, Isfahan University of Medical Sciences, Isfahan 81746-73461, Iran.
Clinical nutrition research
|May 24, 2024
概括
根据对随机对照试验的元分析,大豆补充剂不会显著改变成人血清皮素水平. 需要进一步的研究来探索不同条件下的潜在影响.
科学领域:
- 营养科学 营养科学
- 代谢健康 代谢健康
- 临床研究 临床研究
背景情况:
- 血清阿迪波涅丁的低水平与慢性疾病有关.
- 豆对阿迪波内克丁水平的影响在当前的研究中是不一致的.
研究的目的:
- 系统地审查和对随机对照试验 (RCT) 对大豆对成人血清脂肪素的影响进行元分析.
- 提供对现有证据的全面分析.
主要方法:
- 在PubMed,Scopus,Web of Science和Cochrane图书馆数据库中进行系统搜索,直到2024年3月.
- 使用随机效应模型对9个符合条件的RCT进行元分析.
- 评估异质性和出版偏见.
主要成果:
- 大豆补充剂对阿迪波涅丁度没有显著影响 (WMD = -0.24 μg/mL,p = 0.72).
- 在研究中观察到显著的异质性 (I2 = 89.8%,p < 0.001).
- 敏感性分析和出版偏差评估没有改变总体发现.
结论:
- 大豆补充剂不会显著影响成年人血清阿迪波内克水平.
- 需要进一步进行高质量的RCT,持续时间更长,剂量更高,人群多样化.
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