在老年癌症患者中减少化疗初级剂量:回顾性队列
Wafa Bouleftour1, Fabien Tinquaut2, Ludovic Lafaie3
1Institut de Cancérologie et d'Hématologie Universitaire de Saint-Étienne, CHU de Saint Etienne, Saint Etienne, France.
在第一疗程化疗中,初级剂量减少 (PDR) 显著降低了70岁以上老年患者的毒性率. 这种方法为老年固体瘤患者提供了更安全的化疗选择.
科学领域:
- 在瘤学瘤学.
- 老年医学 老年医学
- 临床药理学 临床药理学
背景情况:
- 主要剂量降低 (PDR) 是一种经验策略,通常应用于接受化疗的老年人.
- 对于老年患者 (70岁以上) 具有固体瘤的化疗剂量,由于潜在的毒性增加,需要仔细考虑.
- 标准化的老年人评估与PDR相关的作用尚未完全阐明.
研究的目的:
- 评估PDR在初始化疗周期对老年患者有固体瘤的毒性率的影响.
- 为了比较接受标准剂量化疗和接受PDR的患者之间的毒性发病率.
- 评估在这个患者群体中使用标准化的老年医疗评估.
主要方法:
- 分析了一组179名70岁及以上的患者,他们接受了第一次针对固体瘤的化疗疗程.
- 患者根据他们是否接受标准化疗剂量或PDR而被分类.
- 毒性率被记录下来,并在两组之间进行比较. 还收集了老年人评估数据.
主要成果:
- 30.2%的患者接受了PDR,而69.8%的人接受了标准剂量.
- 只有29.6%的患者接受了标准化的老年医疗评估.
- 在标准剂量组中,毒性率为83.2%,而在PDR组中为68%,表明PDR显著降低.
结论:
- 第一个化疗周期的PDR与老年患者中毒性率显著降低有关.
- 降低化疗剂量可能是老年人患有固体瘤的更安全策略.
- 进一步研究将老年评估与PDR整合起来,可以优化治疗结果.
更多相关视频
06:20Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition
Published on: March 11, 2021
06:46Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery
Published on: September 27, 2024
相关概念视频
Cancer Therapies
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Combination Therapies and Personalized Medicine
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists
Cancer Prevention
Some...
Cancer Survival Analysis
Targeted Cancer Therapies
There are several types of targeted therapies against...
