固体癌症患者的COVID-19疫苗免疫反应:一个元分析
Tiantian Hua1, Ru Fan2, Yang Fan1
1Department of Epidemiology and Health Statistics, School of Public Health, Southeast University, Nanjing, China.
Human vaccines & immunotherapeutics
|May 24, 2024
概括
与健康人群相比,固体癌症患者的COVID-19疫苗血清转化率较低,特别是在第一剂后. 推进行增剂注射,以提高疫苗在这个脆弱群体中的有效性.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
背景情况:
- 固体癌症患者面临COVID-19感染的更高风险,包括严重的并发症和较差的预后.
- 癌症患者对COVID-19疫苗接种的免疫反应可能不同,需要定制的免疫策略.
- 关于COVID-19疫苗在固体癌症患者中有效性的证据有限.
研究的目的:
- 在患有固体恶性瘤的患者中,评估COVID-19疫苗接种后的血清学反应和疫苗有效性.
- 将癌症患者的免疫反应与健康对照者的免疫反应进行比较.
- 为指导固体癌症患者免疫计划提供证据.
主要方法:
- 进行了系统的文献综述和元分析.
- 搜索了MEDLINE,Embase,科学网,科克莱恩图书馆和clinicaltrials.gov的相关研究.
- 汇集的血清转化率是使用随机效应模型计算的,其中包括66项研究,包括13050名癌症患者和8550名对照.
主要成果:
- 在第一剂COVID-19疫苗接种后,癌症患者的综合血清阳性率为55.2%,对照组为90.2%.
- 随着随后的剂量增加,率增加了:87.6% (癌症) 和98.9% (对照组) 在第二剂量后,以及91.4% (癌症) 和99.8% (对照组) 在第三剂量后.
- 亚组分析表明,样本大小,抗体测试时间和疫苗类型影响了结果.
结论:
- 在固体癌症患者中,COVID-19疫苗血清转化率明显较低,特别是在初始剂量后.
- 随后的接种疫苗或强剂对于提高疫苗在这个人群中的有效性至关重要.
- 这些发现支持对固体癌症患者进行优化疫苗接种计划的需求.
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