ангиопоэтин作为预测指数在COVID-19患者在三角洲和欧米克朗波浪中的预测指数
Panagiota Tsiatsiou1, Kyriakos Kouirouxis1, Vasiliki Tsaireli1
1Department of Microbiology, AHEPA University Hospital, School of Medicine, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.
Current issues in molecular biology
|May 24, 2024
概括
ангиопоетин-2/ ангиопоетин-1 的比率有效地表明COVID-19的严重程度和患者的预后. 监测这种比率有助于临床医生识别有风险的患者并个性化治疗以获得更好的结果.
科学领域:
- 生物化学 生物化学
- 医学研究 医学研究
- 免疫学 免疫学 免疫学
背景情况:
- 血管新生素-1 (Ang-1) 和血管新生素-2 (Ang-2) 是血管新生和血管完整性的关键调节剂.
- Ang-1和Ang-2水平的不平衡与各种炎症和血管疾病有关.
- ангиопоетин-2/ ангиопоетин-1 (Ang-2/Ang-1) 的比率越来越被认为是疾病严重程度的潜在生物标志物.
研究的目的:
- 研究Ang-1,Ang-2度和Ang-2/Ang-1比率与COVID-19患者的临床结果之间的相关性.
- 评估这些生物标志物的实用性,以评估疾病严重程度和预测2019年新冠肺炎疾病的生存率.
- 要确定Ang-2/Ang-1比率是否与单个Ang-1和Ang-2水平相比,作为一个优越的指标.
主要方法:
- 一项队列研究涉及90名成年COVID-19患者:30名在重症监护室 (ICU),30名在非ICU病房,以及30名无症状对照.
- 测量Ang-1和Ang-2度以计算Ang-2/Ang-1比率.
- 分析Ang-1,Ang-2水平和Ang-2/Ang-1比率作为潜在的严重性指标.
- 接收器操作特征 (ROC) 分析,以确定区分患者组的最佳门.
主要成果:
- 在门诊和住院COVID-19患者之间观察到Ang-1和Ang-2水平的统计学上显著差异.
- Ang-2/Ang-1比率在所有个体患者组 (门诊患者,非ICU,ICU) 中显示出显著的差异.
- 在ROC分析中,确定了用于区分患者严重程度水平的特定Youden指数值.
- 与单个Ang-1和Ang-2水平相比,Ang-2/Ang-1比率显示出更好的预后和诊断效用.
结论:
- Ang-2/Ang-1比率是评估COVID-19疾病严重程度和患者预后的有价值生物标志物.
- 监测Ang-2/Ang-1比率可以帮助识别患有严重结局风险较高的患者.
- 这种生物标志物可以帮助临床医生量身定制治疗策略,以改善2019年冠状病毒病患者的临床结果.
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