牙破的唾液诊断:一个系统的审查
Rita Antonelli1, Valentina Massei1, Elena Ferrari2
1Centro Universitario di Odontoiatria, Department of Medicine and Surgery, University of Parma, 43126 Parma, Italy.
Current issues in molecular biology
|May 24, 2024
概括
唾液生物标志物在诊断牙损伤方面表现有前途. 这项系统性审查发现健康人和虫患者之间的唾液分子存在显著差异,这表明有诊断潜力.
科学领域:
- 生物分子分析.
- 口腔卫生诊断口腔卫生诊断口腔卫生诊断口腔卫生诊断口腔卫生诊断口腔卫生诊断口腔卫生诊断口腔卫生诊断
- 系统审查方法论 系统审查方法论
背景情况:
- 牙腐烂是多因素的,并且改变了唾液的组成.
- 准确诊断牙损伤对于有效管理至关重要.
- 现有的诊断方法可以从补充生物标志物方法中受益.
研究的目的:
- 系统地审查唾液生物标志物的可靠性,以诊断牙损伤.
- 为了识别特定的唾液分子与牙损伤的潜在诊断价值.
- 评估关于液生物标志物在虫检测中的证据质量.
主要方法:
- 按照PRISMA指南进行系统审查.
- 在Medline,Web of Science和Scopus数据库中进行的搜索.
- 包括使用DMFT和ICDAS标准对有/没有的健康受试者进行的研究.
主要成果:
- 包括16项研究,所有这些研究报告了脏受影响和健康个体之间的唾液分子显著差异 (p <0.05).
- 蛋白质,特别是α-氨酶和粘蛋白,经常被研究.
- 中等到高质量的证据表明唾液粘蛋白,糖蛋白 (sCD14),介质蛋白,尿素酶,碳酸无水素酶VI和尿素显示出诊断潜力.
结论:
- 唾液生物标志物显示出可靠的牙损伤诊断的潜力.
- 特定的分子,如粘蛋白,sCD14,介质蛋白,尿素酶,碳酸无水酶VI和尿素等,需要进一步研究.
- 虽然一些研究存在局限性,但总体证据支持某些唾液化合物在牙损中的诊断作用.
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