在免疫检查点抑制剂心肌炎中增加IL-6和瘤坏死因子-α
Abdelrahman Ali1, Rebecca Caldwell1, Gaspar Pina1
1Department of Cardiology, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Unit 1451, Houston, TX 77030, USA.
Diseases (Basel, Switzerland)
|May 24, 2024
概括
免疫检查点抑制剂 (ICI) 心肌炎中常见的介质素-6和瘤亡因子-α的升高,但不能预测结果. 这些细胞因子水平目前为ICI心肌炎患者的预后或指导治疗提供了有限的价值.
科学领域:
- 心脏病学 心脏病学
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
背景情况:
- 免疫检查点抑制剂 (ICI) 可以引起心肌炎,这是一个严重的副作用.
- 在ICI心肌炎中,外周细胞因子水平的预后和治疗影响尚不清楚.
研究的目的:
- 确定能够预测ICI心肌炎患者的预后和指导治疗决策的特定细胞因子.
- 调查细胞因子水平升高与临床结果之间的关联.
主要方法:
- 对65名ICI心肌炎患者进行了回顾性队列研究.
- 对周围血液中细胞因子水平的分析,包括互白素-6 (IL-6) 和瘤缩因子-α (TNF-α).
- 重大心血管不良事件 (MACE) 和90天死亡率的评估.
主要成果:
- 在ICI心肌炎患者中,IL-6 (74%) 和TNF-α (68%) 的升高是常见的.
- 在患有高于正常IL-6或TNF-α水平的患者之间,没有观察到90天死亡率或MACE的显著差异.
- 治疗infliximab并没有显著影响MACE或生存结果.
结论:
- 虽然IL-6和TNF-α在ICI心肌炎中经常升高,但它们似乎不是可靠的预后标志物.
- 当前的外周细胞因子水平在指导ICI心肌炎的免疫调节治疗方面具有有限的效用.
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