新的缓冲盐保护的甲酸盐通过改善肠道组织形态,屏障功能,抗氧化能力和肉的微生物群体来促进生长性能
Mebratu Melaku1,2, Dan Su1, Huaibao Zhao1
1State Key Laboratory of Animal Nutrition and Feeding, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China.
Biology
|May 24, 2024
概括
新的酸缓冲溶液 (NSB) 显著改善肉生长性能和肠道健康. NSB提高了料摄入量和体重增加,同时降低了料转换率,显示出作为抗生素替代品的潜力.
科学领域:
- 动物科学动物科学
- 营养科学 营养科学
- 微生物学 微生物学
背景情况:
- 抗生素在肉生产中被广泛使用,但由于耐药性问题而面临越来越多的限制.
- 酸是一种有前途的替代品,但它的有效性可能受到其释放特征的限制.
- 开发了一种新型的缓冲 natrium butyrate (NSB),以提高其稳定性和生物可用性.
研究的目的:
- 为了评估一种新的缓冲 natrium butyrate (NSB) 作为肉生产中的抗生素替代品的有效性.
- 评估NSB对生长性能,血清抗炎细胞因子,肠道形态,肠道屏障功能,抗氧化参数,短链脂肪酸 (SCFA) 含量和菌群的影响.
主要方法:
- 192只肉被分为三个组:对照组 (CON),抗生素组 (ANT) 和NSB.
- 饮食补充了青红素 (ANT) 或NSB.
- 分析了生长表现,血清细胞因子,肠道组织学,肠道屏障蛋白,抗氧化状态,SCFA和菌群.
主要成果:
- NSB显著改善了平均每日料摄入量 (ADFI) 和平均每日取量 (ADG),并降低了料转换比率 (FCR).
- NSB上调抗炎IL-10和下调促炎TNF-α,增加阴和阴小的高度 (VH) 和VH/CD比率,并增强了肠道屏障蛋白 (ZO-1,克劳丁-1,奥克卢丁,粘素-2).
- NSB增强了抗氧化能力 (SOD,T-AOC/MDA比率),增加了头和阴中的和黄油酸含量,并丰富了有益的SCFA生产细菌,如*Colidextribacter*和*Peptostreptococcaceae*.
结论:
- 补充NSB有效地通过改善肠道形态,屏障功能和抗氧化剂状况来提高 brojler 的生长性能.
- NSB调节血清抗炎细胞因子,并促进有益的肠道微生物群组成,从而增加SCFA的产生.
- 新型缓冲酸 (NSB) 显示出作为禽类抗生素增长促进剂的安全有效替代品的巨大潜力.
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