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Updated: Jun 25, 2025

Nucleoside Triphosphates - From Synthesis to Biochemical Characterization
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Published on: April 3, 2014

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在dNTP选择子域中,SNP相关的氨基酸残留替代物降低了聚β聚合酶活性

Olga A Kladova1, Timofey E Tyugashev1, Aleksandr A Miroshnikov2

  • 1Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of Russian Academy of Sciences, 630090 Novosibirsk, Russia.

Biomolecules
|May 24, 2024
PubMed
概括

在DNA聚合酶β (Polβ) 基因中的单核酸多态性可以改变其功能. 变种G274R,G290C和R333W显示活动减少,可能增加未修复的DNA损伤.

关键词:
在DNA聚合酶ββ的过程中,修复DNA的修复DNA的修复酶活性的酶活性.一个核酸的多态性.

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