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相关概念视频

Role of Skin in Vitamin D Synthesis01:23

Role of Skin in Vitamin D Synthesis

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The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
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Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

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The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
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Synthesis and Functions of Calcitonin00:51

Synthesis and Functions of Calcitonin

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Calcitonin, a vital polypeptide hormone, regulates calcium levels within body fluids. It is released by the parafollicular cells, also known as C cells, situated in the follicular epithelium of the thyroid gland. Calcitonin responds to fluctuations in blood calcium levels and the influence of gastrointestinal hormones like gastrin and cholecystokinin.
The exact mechanisms by which calcitonin operates in calcium homeostasis remain elusive, but its significance is evident in several vital...
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Protein Organization01:24

Protein Organization

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Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
The primary structure of a protein is its amino acid sequence....
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Protein and Protein Structure02:15

Protein and Protein Structure

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Proteins are one of the most abundant organic molecules in living systems and have the most diverse range of functions of all macromolecules. Proteins may be structural, regulatory, contractile, or protective. They may serve in transport, storage, or membranes; or they may be toxins or enzymes. Their structures, like their functions, vary greatly. They are all, however, amino acid polymers arranged in a linear sequence.
A protein's shape is critical to its function. For example, an enzyme...
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Connective Tissue Cell Types01:22

Connective Tissue Cell Types

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Connective tissue develops from the mesoderm of a developing embryo and consists of cells, fibers, and ground substance: a gel-like material containing large complexes of carbohydrates and proteins. Connective tissue was first identified as a separate tissue family in the 18th century, and Johannes Peter Muller coined the term connective tissue.
Fat cells (adipocytes), smooth muscle cells (myoblasts), and bone cells (osteoblasts) are some connective tissue cell types. Some immune system cells...
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相关实验视频

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A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
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4-Hydroxy-1α,25-Dihydroxyvitamin D:合成和结构功能研究

Carole Peluso-Iltis1,2,3,4, Noé Pierrat1,2,3,4, Daniela Rovito1,2,3,4

  • 1Institute of Genetics and Molecular and Cellular Biology (IGBMC), 67400 Illkirch, France.

Biomolecules
|May 24, 2024
PubMed
概括

新的维生素D类型,1,4α,25(OH) 3D3和1,4β,25(OH) 3D3,显示出强烈的活性. 这些4-基维生素D衍生物调节基因表达并诱导高血症,类似于母化合物.

关键词:
卡尔西米亚是什么意思结构功能 结构功能综合合成是一种合成.维生素D的代谢产物维生素D的代谢产物

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Author Spotlight: Unraveling Vitamin A Transport Mechanisms — Linking Liver Receptors to Vision Health Through RBPR2 and RBP4 Interactions
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Isolation of Mesenchymal Stem Cells from Human Alveolar Periosteum and Effects of Vitamin D on Osteogenic Activity of Periosteum-derived Cells
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科学领域:

  • 生物化学 生物化学
  • 内分泌学 在内分泌学.
  • 分子生物学分子生物学

背景情况:

  • 像25-基维生素D (25D) 和1,25-二基维生素D (1,25D) 这样的活性维生素D代谢物对细胞功能至关重要.
  • 其他代谢途径,包括25D的4-基化,有助于维生素D的代谢.

研究的目的:

  • 探索1,25D3的4-基衍生物的结构-活性关系.
  • 评估新型4-基维生素D类型的生物活性.

主要方法:

  • 对1,4α,25(OH) 3D3和1,4β,25(OH) 3D3的结构分析.
  • 在大鼠肠道上皮细胞中评估VDR基因表达.
  • 在小鼠中诱导高血症的评估.

主要成果:

  • 1,4α,25(OH) 3D3和1,4β,25(OH) 3D3通过维持和额外的相互作用稳定VDR活性构造.
  • 这些新型类似物在调节VDR标基因表达方面表现出与1,25D3相当的功效.
  • 4-基衍生物在小鼠中诱导高血症,剂量类似于1.25D.

结论:

  • 通过4-基化途径产生强效的维生素D类似物.
  • 1,4α,25(OH) 3D3和1,4β,25(OH) 3D3由于它们的VDR介导活动和体内效应,代表了进一步研究的有希望的化合物.