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对于急性神经疾病的MSCs的预先条件:从细胞到功能影响 - 一个系统性审查

Inês Serrenho¹, Susana Alves Ferreira¹, Graça Baltazar²

¹Centro de Investigação em Ciências da Saúde (CICS-UBI), Universidade da Beira Interior, 6200-506 Covilhã, Portugal.

|May 24, 2024

概括

预先条件化介质干细胞 (MSCs) 增强了它们在神经系统损伤方面的治疗潜力. 多种不同的策略可以改善MSC的生存,迁移和功能,从而导致更好的组织修复和功能恢复,没有不良影响.

科学领域:

神经科学是一个神经科学.
再生医学是一种再生医学.
细胞生物学细胞生物学

背景情况:

介质细胞干细胞 (MSCs) 在治疗神经系统损伤方面表现有前途.
优化MSC的治疗疗效需要了解预先条件的机制.

研究的目的:

系统地审查有关MSC预先条件化策略的证据.
分析它们对治疗神经系统损伤的影响.

主要方法:

对52项研究进行了系统审查.
分析了九种不同的预条件方法 (例如,氧气操纵,化学暴露,物理力,3D培养).

主要成果:

预先条件改变了MSC的生存,迁移,表型,机密和蛋白质.
观察到增强的MSC定位,集成和治疗因素的分泌.
预先条件的MSC促进了再生,减少了神经炎症,并在动物中风,TBI和SCI模型中改善了功能恢复.

结论:

所有审查的预条件化策略都刺激了增强MSC治疗效果的途径.
没有报告任何不良影响;结合策略可能进一步提高疗效并解决捐赠者的变异性.

关键词:

缺血性疾病缺血性疾病介质细胞干细胞介质细胞干细胞这是一个预先条件.干细胞疗法是一种干细胞疗法.它具有治疗潜力.创伤性疾病是创伤性疾病.

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相关概念视频

Mesenchymal Stem Cells

Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...